Feki I, Ben Hmida M, Masmoudi H, Triki C, Bahloul Z, Hachicha J, Jlidi R, Mhiri C
Service de Neurologie, Centre Hospitalo-universitaire de Sfax, Tunisie.
Rev Neurol (Paris). 1997 Mar;153(2):138-40.
Central nervous system involvement in systemic lupus erythematosus (SLE) is frequent and severe, however, myelopathy is rarely reported (0.8 p. 100 of SLE cases). We describe two SLE-young women. They were 21 and 37 year old, presented with acute paraplegia. CSF study showed pleocytosis and moderately elevated protein. Antinuclear, anti-DNA and anticardiolipin were positive. High dose steroids therapy induced marked improvement. The pathogenesis of myelopathy in SLE remains unclear. Anti-phospholipid antibodies may cause thrombosis and ischemic myelopathy. However, auto-antibodies directed against central nervous system constituents may be involved.
系统性红斑狼疮（SLE）累及中枢神经系统很常见且病情严重，然而，脊髓病却鲜有报道（每100例SLE病例中有0.8例）。我们描述了两名年轻的SLE女性患者。她们分别为21岁和37岁，表现为急性截瘫。脑脊液检查显示有细胞增多以及蛋白中度升高。抗核抗体、抗双链DNA抗体和抗心磷脂抗体均为阳性。大剂量类固醇治疗后病情显著改善。SLE脊髓病的发病机制仍不清楚。抗磷脂抗体可能导致血栓形成和缺血性脊髓病。然而，针对中枢神经系统成分的自身抗体可能也参与其中。
