Sas R, Dawes C
Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada.
Arch Oral Biol. 1997 Jul;42(7):469-74. doi: 10.1016/s0003-9969(97)00045-9.
The objective was to determine the percentage contribution of parotid saliva to whole saliva and to the saliva at 11 sites in the mouth, when flow rate was unstimulated or stimulated with chewing-gum. The marker substance used was alpha-amylase, as this is in much higher concentration in parotid saliva than in secretions from other salivary glands. Formulae were derived for calculation of the minimum, maximum, and mean percentage contributions of parotid saliva to saliva in different areas of the mouth. The results, from 10 individuals, showed that the contributions of parotid to unstimulated and stimulated whole saliva averaged 30.1% and 35.6%, respectively, whereas the corresponding values for samples from the region vestibular to the upper molars were 56.1% and 61.4%, but only 2.8% and 6.8% for samples from an area vestibular to the upper incisors. Thus parotid saliva was not evenly distributed throughout the mouth. Stimulated samples mostly contained significantly higher proportions of parotid saliva, but the distribution of the parotid saliva was still extremely variable. Because the different regions of the mouth are not exposed to the same fluid environment, this may influence the site-specificity of supragingival calculus deposition and of various diseases such as dental caries.
目的是确定在未刺激或用口香糖刺激时，腮腺唾液对全唾液以及口腔内11个部位唾液的百分比贡献。所使用的标记物质是α-淀粉酶，因为其在腮腺唾液中的浓度远高于其他唾液腺的分泌物。推导了用于计算腮腺唾液对口腔不同区域唾液的最小、最大和平均百分比贡献的公式。来自10名个体的结果表明，腮腺对未刺激和刺激全唾液的贡献分别平均为30.1%和35.6%，而来自上颌磨牙前庭区域样本的相应值为56.1%和61.4%，但来自上颌切牙前庭区域样本的相应值仅为2.8%和6.8%。因此，腮腺唾液在口腔内分布不均。刺激样本中腮腺唾液的比例大多显著更高，但腮腺唾液的分布仍然极具变异性。由于口腔的不同区域暴露于不同的流体环境，这可能会影响龈上牙石沉积以及诸如龋齿等各种疾病的部位特异性。
