[浓缩纯化培养抗狂犬病疫苗的灭活方法研究]
[Study of methods of inactivating a concentrated, purified cultured antirabies vaccine].
作者信息
Krutilina D V, Dulina A V, Morozova V M, Mad'iarova R S, Kovliasova E K
出版信息
Vopr Virusol. 1977 Sep-Oct(5):586-8.
PMID:930053
Abstract
Two methods of inactivation, with ultraviolet (UV) and gamma (gamma) rays, of the concentrated purified tissue culture rabies vaccine from the Vnukovo-32 strain were studied. Under the optimal conditions of treatment of 100-fold concentrated purified virus-containing suspension, a completely inactivated vaccine with high immunogenicity indices (4.1 to 78) was obtained. Both the inactivation methods were found to be of equal value.
摘要
研究了用紫外线（UV）和γ射线对来自伏努科沃-32株的浓缩纯化组织培养狂犬病疫苗进行两种灭活方法。在对100倍浓缩的含纯化病毒悬浮液进行最佳处理条件下，获得了具有高免疫原性指数（4.1至78）的完全灭活疫苗。发现这两种灭活方法具有同等价值。
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