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[浓缩纯化培养抗狂犬病疫苗的灭活方法研究]

[Study of methods of inactivating a concentrated, purified cultured antirabies vaccine].

作者信息

Krutilina D V, Dulina A V, Morozova V M, Mad'iarova R S, Kovliasova E K

出版信息

Vopr Virusol. 1977 Sep-Oct(5):586-8.

PMID:930053
Abstract

Two methods of inactivation, with ultraviolet (UV) and gamma (gamma) rays, of the concentrated purified tissue culture rabies vaccine from the Vnukovo-32 strain were studied. Under the optimal conditions of treatment of 100-fold concentrated purified virus-containing suspension, a completely inactivated vaccine with high immunogenicity indices (4.1 to 78) was obtained. Both the inactivation methods were found to be of equal value.

摘要

研究了用紫外线(UV)和γ射线对来自伏努科沃-32株的浓缩纯化组织培养狂犬病疫苗进行两种灭活方法。在对100倍浓缩的含纯化病毒悬浮液进行最佳处理条件下,获得了具有高免疫原性指数(4.1至78)的完全灭活疫苗。发现这两种灭活方法具有同等价值。

相似文献

1
[Study of methods of inactivating a concentrated, purified cultured antirabies vaccine].[浓缩纯化培养抗狂犬病疫苗的灭活方法研究]
Vopr Virusol. 1977 Sep-Oct(5):586-8.
2
[Experimental study of an antirabies vaccine from sheep brain tissue inactivated by UV rays (author's transl)].紫外线灭活羊脑组织抗狂犬病疫苗的实验研究(作者译)
Vopr Virusol. 1975 Sep-Oct(5):578-81.
3
[Immunogenic activity of cultural antirabies vaccine inactivated by gamma-rays].[γ射线灭活的培养狂犬病疫苗的免疫原活性]
Vopr Virusol. 1977 May-Jun(3):321-3.
4
[Antigenic activity and the reactogenicity of UV ray-inactivated antirabies vaccine from the brain of sheep].[羊脑紫外线灭活抗狂犬病疫苗的抗原活性及反应原性]
Zh Mikrobiol Epidemiol Immunobiol. 1979 Jun(6):39-41.
5
[Antigenic activity of a concentrated and purified cultured antirabies vaccine from the Vnukovo-32-107 strain].[来自伏努科沃-32-107株的浓缩纯化培养抗狂犬病疫苗的抗原活性]
Vopr Virusol. 1977 Sep-Oct(5):581-5.
6
[Effect of specific antibodies on active immunity development in those inoculated with an antirabies vaccine].[特异性抗体对接种狂犬病疫苗者主动免疫形成的影响]
Zh Mikrobiol Epidemiol Immunobiol. 1980 Nov(11):28-30.
7
[Antigenic activity and the reactogenicity of a concentrated, purified, UV-inactivated cultured rabies vaccine].
Zh Mikrobiol Epidemiol Immunobiol. 1983 Sep(9):47-50.
8
[Antigenic activity of a gamma-ray inactivated, concentrated, purified cultured antirabies vaccine].
Zh Mikrobiol Epidemiol Immunobiol. 1978(12):93-6.
9
[Development of a method of inactivation of antirabies vaccine by ultraviolet rays. II. Immunogenic and antigenic properties of antirabies vaccine, inactivated by ultraviolet rays].[紫外线灭活狂犬病疫苗方法的研制。II. 紫外线灭活狂犬病疫苗的免疫原性和抗原性]
Vopr Virusol. 1959 Sep-Oct;4:615-9.
10
[Specific activity of an UV-inactivated antirabies vaccine made from brain tissue administered in a shortened schedule].[采用缩短接种程序接种的由脑组织制成的紫外线灭活抗狂犬病疫苗的比活性]
Zh Mikrobiol Epidemiol Immunobiol. 1982 Apr(4):98-101.