Farhey Y, Hess E V
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267-0563, USA.
Lupus. 1997;6(7):572-7. doi: 10.1177/096120339700600704.
Atherosclerosis may represent a significant cause of death and morbidity in patients with systemic lupus erythematosus. Coronary involvement is more premature in lupus patients. We present the case of a young woman diagnosed with SLE at the age of 20 years who had a myocardial infarction at age 29 years. We review the mechanisms of atherosclerosis, the interrelations between atherosclerosis and autoimmunity, and between atherosclerosis and SLE. We also review the risk factors, influence of disease and treatment and the guidelines for management of accelerated atherosclerosis in lupus patients.
动脉粥样硬化可能是系统性红斑狼疮患者死亡和发病的重要原因。狼疮患者的冠状动脉受累更为提前。我们报告了一例20岁被诊断为系统性红斑狼疮的年轻女性，她在29岁时发生了心肌梗死。我们回顾了动脉粥样硬化的机制、动脉粥样硬化与自身免疫之间以及动脉粥样硬化与系统性红斑狼疮之间的相互关系。我们还回顾了危险因素、疾病和治疗的影响以及狼疮患者加速动脉粥样硬化的管理指南。
