Tayama E, Nakazawa T, Takami Y, Makinouchi K, Ohtsubo S, Ohashi Y, Andrade A J, Glueck J, Mueller J, Nosé Y
Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
Artif Organs. 1997 Jul;21(7):675-9. doi: 10.1111/j.1525-1594.1997.tb03721.x.
While a centrifugal pump is generally used for nonpulsatile blood flow, it can also produce a pulsatile flow by alternating the impeller rotational speed (rpm) periodically. However, there is a concern that this centrifugal pump pulsatile mode may induce added hemolysis as a result of the repeated acceleration and deceleration of rpm. Thus, a hemolysis study of the pulsatile modes of the Gyro C1E3 centrifugal pump (Gyro-P) was conducted. The results were then compared with the nonpulsatile mode of the same pump (Gyro-N) and the nonpulsatile BioMedicus BP-80 (Bio-N) pump. Three different conditions were simulated: left ventricular assist device (LVAD), cardiopulmonary bypass (CPB), and percutaneous cardiopulmonary support (PCPS). The beating rate of the Gyro-P was set at 40 bpm, with repetition of two different impeller speed (the lower being 70% of the higher speed). The 2 impeller speeds were set to obtain the same average flow as that of the nonpulsatile mode. The hemolysis results of the Gyro-P were comparable to or better than those of Bio-N, and no excessive hemolysis was observed, compared to the Gyro-N. In conclusion, The Gyro-P had an excellent hemolytic characteristic and generated no excessive hemolysis in most clinical usage conditions. With the concern of hemolysis eliminated, this pulsatile mode may have various possible mode advantages.
虽然离心泵通常用于产生非搏动性血流，但它也可以通过周期性地改变叶轮转速（rpm）来产生搏动性血流。然而，有人担心这种离心泵搏动模式可能会由于转速的反复加速和减速而导致额外的溶血。因此，对Gyro C1E3离心泵（Gyro-P）的搏动模式进行了溶血研究。然后将结果与同一泵的非搏动模式（Gyro-N）和非搏动性BioMedicus BP-80（Bio-N）泵进行比较。模拟了三种不同的情况：左心室辅助装置（LVAD）、体外循环（CPB）和经皮心肺支持（PCPS）。Gyro-P的搏动频率设定为40次/分钟，重复两种不同的叶轮转速（较低转速为较高转速的70%）。设置这两种叶轮转速以获得与非搏动模式相同的平均流量。Gyro-P的溶血结果与Bio-N相当或更好，与Gyro-N相比，未观察到过度溶血。总之，Gyro-P具有优异的溶血特性，在大多数临床使用条件下不会产生过度溶血。随着对溶血问题的担忧消除，这种搏动模式可能具有多种潜在优势。
