Noyes H A, Arana B A, Chance M L, Maingon R
Liverpool School of Tropical Medicine, UK.
J Eukaryot Microbiol. 1997 Sep-Oct;44(5):511-7. doi: 10.1111/j.1550-7408.1997.tb05732.x.
The relationships of the Leishmania hertigi complex and the lizard Leishmania species to the main groups of mammalian Leishmania and Endotrypanum parasites were examined. Restriction fragment length polymorphisms and sequences of small subunit ribosomal RNA genes and hybridization studies of kinetoplast DNA indicated that the L. hertigi complex was more closely related to the genus Endotrypanum than to the genus Leishmania. The lizard Leishmania species were found to be at the crown of the Leishmania tree. The data provides strong evidence for a Neotropical origin of the Endotrypanum/Leishmania clade since the parasites closest to the root of the tree are all found exclusively in the Neotropics. The evolution of the Leishmania/Endotrypanum clade in relation to the evolution of the known hosts of these parasites is discussed.
研究了赫氏利什曼原虫复合体及蜥蜴利什曼原虫物种与哺乳动物利什曼原虫和内锥虫寄生虫主要类群之间的关系。限制性片段长度多态性、小亚基核糖体RNA基因序列以及动基体DNA杂交研究表明，赫氏利什曼原虫复合体与内锥虫属的关系比与利什曼原虫属的关系更为密切。发现蜥蜴利什曼原虫物种位于利什曼原虫谱系的顶端。这些数据为内锥虫/利什曼原虫进化枝起源于新热带地区提供了有力证据，因为最接近该谱系根部的寄生虫均仅在新热带地区被发现。本文还讨论了利什曼原虫/内锥虫进化枝相对于这些寄生虫已知宿主进化的情况。
