Jorm A F
NH & MRC Psychiatric Epidemiology Research Centre, Australian National University, Canberra, Australia.
Alzheimer Dis Assoc Disord. 1997 Sep;11(3):158-62.
A meta-analysis was performed on 10 studies that directly compared an informant questionnaire with a brief cognitive test at screening for dementia. The effectiveness (effect size) of the screening tests used in each study was measured using the standardized difference between the means of the demented and control samples. The informant questionnaires were found to have a weighted mean effectiveness of 1.74 [95% confidence interval (CI): 1.39-2.09], whereas for the cognitive tests, the mean was 1.48 (95% CI: 1.23-1.73). These means translate into sensitivities and specificites of 0.86 and 0.80 for informant questionnaires, compared with 0.79 and 0.80 for brief cognitive tests. The effectiveness of the informant questionnaires was found to differ significantly from study to study, but the reason for this variation is not clear. It was concluded that informant questionnaires are as effective as brief cognitive tests at screening for dementia and deserve to be used more extensively.
对10项研究进行了荟萃分析，这些研究在痴呆筛查时直接将 informant问卷与简短认知测试进行了比较。每项研究中使用的筛查测试的有效性（效应大小）通过痴呆样本和对照样本均值之间的标准化差异来衡量。结果发现， informant问卷的加权平均有效性为1.74 [95%置信区间（CI）：1.39 - 2.09]，而认知测试的均值为1.48（95% CI：1.23 - 1.73）。这些均值转化为 informant问卷的敏感性和特异性分别为0.86和0.80，而简短认知测试的敏感性和特异性分别为0.79和0.80。结果发现， informant问卷的有效性在不同研究之间存在显著差异，但这种差异的原因尚不清楚。研究得出结论， informant问卷在痴呆筛查方面与简短认知测试同样有效，值得更广泛地使用。
