de Waard-van der Spek F B, Mulder P G, Oranje A P
Department of Dermatology and Venereology, University Hospital Rotterdam, The Netherlands.
J Am Acad Dermatol. 1997 Sep;37(3 Pt 1):418-21. doi: 10.1016/s0190-9622(97)70143-9.
Prilocaine-lidocaine emulsion (EMLA) has been used successfully as a local anesthetic in patients undergoing superficial procedures.
The purpose of this study was to investigate the analgesic effect of the patch as a local anesthetic for children undergoing a skin biopsy procedure. The effect on both the pain at the injection site and the pain of the biopsy was investigated.
The study was randomized, double blinded, and placebo controlled. Of the 63 children randomly recruited into the study, 60 children were evaluated; the remaining three were withdrawn from the study.
The anesthetic patch was significantly more effective than the placebo patch in decreasing pain at the injection site. No significant difference in pain scores of the biopsy procedure was found between the study groups. No serious side effects were observed.
The anesthetic patch reduced the pain experienced by children subjected to a skin biopsy procedure.
丙胺卡因 - 利多卡因乳剂（EMLA）已成功用于接受浅表手术的患者的局部麻醉。
本研究的目的是调查该贴剂作为局部麻醉剂对接受皮肤活检手术的儿童的镇痛效果。研究了其对注射部位疼痛和活检疼痛的影响。
该研究为随机、双盲、安慰剂对照试验。在随机招募进入研究的63名儿童中，对60名儿童进行了评估；其余3名退出研究。
在减轻注射部位疼痛方面，麻醉贴剂比安慰剂贴剂显著更有效。研究组之间在活检手术的疼痛评分上未发现显著差异。未观察到严重副作用。
麻醉贴剂减轻了接受皮肤活检手术的儿童所经历的疼痛。
