van der Bom J G, de Maat M P, Bots M L, Hofman A, Kluft C, Grobbee D E
Department of Epidemiology & Biostatistics, Erasmus University Medical School, and the Netherlands Institute for Health Sciences, Rotterdam.
Thromb Haemost. 1997 Sep;78(3):1059-62.
As evidence accumulates to implicate fibrinogen as a risk indicator for cardiovascular disease, it is of interest to study its seasonal variation. A population based cross-sectional study was performed among participants of the Rotterdam Study, a cohort of 7,983 men and women, aged 55 years and over. Fibrinogen levels were measured by the prothrombin time derived method in the first 2,325 participants of the study. Fibrinogen levels were considerably higher in winter. The seasonal difference was 0.34 g/l (95% confidence interval 0.29, 0.39) and was more pronounced in subjects aged 75 years and over than in subjects aged 55 to 75 years, 0.43 g/l (0.34, 0.52) and 0.29 g/l (0.24, 0.35), respectively. Additional adjustment for body mass index, systolic and diastolic blood pressure, and total and HDL cholesterol did not materially change the findings. After adjustment for seasons, outdoor temperature was not associated with fibrinogen. Adjustment for outdoor temperature did not change the seasonal variation of fibrinogen, seasonal difference 0.31 g/l (0.24, 0.37). In conclusion, fibrinogen levels are highest in Winter. The seasonal variation of fibrinogen is more pronounced in the elderly. Outdoor temperature does not seem to play a role in the seasonal variation of fibrinogen. Seasonal variation of fibrinogen may partly explain the increased cardiovascular disease mortality in Winter.
随着越来越多的证据表明纤维蛋白原是心血管疾病的风险指标，研究其季节性变化就变得很有意义。我们在鹿特丹研究的参与者中开展了一项基于人群的横断面研究，该队列包括7983名年龄在55岁及以上的男性和女性。通过凝血酶原时间衍生法对该研究的前2325名参与者测量了纤维蛋白原水平。冬季的纤维蛋白原水平显著更高。季节差异为0.34 g/l（95%置信区间0.29，0.39），在75岁及以上的受试者中比在55至75岁的受试者中更为明显，分别为0.43 g/l（0.34，0.52）和0.29 g/l（0.24，0.35）。对体重指数、收缩压和舒张压以及总胆固醇和高密度脂蛋白胆固醇进行额外调整后，研究结果没有实质性变化。在对季节进行调整后，室外温度与纤维蛋白原无关。对室外温度进行调整并没有改变纤维蛋白原的季节性变化，季节差异为0.31 g/l（0.24，0.37）。总之，纤维蛋白原水平在冬季最高。纤维蛋白原的季节性变化在老年人中更为明显。室外温度似乎在纤维蛋白原的季节性变化中不起作用。纤维蛋白原的季节性变化可能部分解释了冬季心血管疾病死亡率的增加。
