Thines E, Anke H, Steglich W, Sterner O
Lehrbereich Biotechnologie der Universität Kaiserslautern, Germany.
Z Naturforsch C J Biosci. 1997 Jul-Aug;52(7-8):413-20. doi: 10.1515/znc-1997-7-801.
Four new botrydial derivatives, hymendial (1), 7 alpha-hydroxydihydrobotrydial (2), 7 alpha-hydroxy-10-O-methyldihydrobotrydial (4), and 7 alpha-acetoxy-15 alpha-methoxy-10-O-methyl-dihydrobotrydial (5) were isolated together with dihydrobotrydial (3) from the culture fluid of the ascomycete Hymenoscyphus epiphyllus. In addition, cytochalasin H (6a), 18-deoxycytochalasin H (6b) and (+)-mellein (7) were produced by this fungus. Hymendial (1), possessing an alpha, beta-unsaturated dialdehyde functionality, exhibits antimicrobial and cytotoxic activities and is mutagenic in the Ames Salmonella assay.
从子囊菌叶生膜盘菌的培养液中分离出了四种新的葡萄孢菌素衍生物，即膜盘菌素（1）、7α-羟基二氢葡萄孢菌素（2）、7α-羟基-10-O-甲基二氢葡萄孢菌素（4）和7α-乙酰氧基-15α-甲氧基-10-O-甲基二氢葡萄孢菌素（5），同时还分离出了二氢葡萄孢菌素（3）。此外，该真菌还产生了细胞松弛素H（6a）、18-脱氧细胞松弛素H（6b）和（+）-蜂蜜曲菌素（7）。膜盘菌素（1）具有α,β-不饱和二醛官能团，表现出抗菌和细胞毒性活性，并且在艾姆斯沙门氏菌试验中具有致突变性。
