体液中两性霉素B浓度的放射性测定
Radiometric determination of the concentration of amphotericin B in body fluids.
作者信息
Hopfer R L, Gröschel D
出版信息
Antimicrob Agents Chemother. 1977 Dec;12(6):733-5. doi: 10.1128/AAC.12.6.733.
Abstract
A new assay was developed to determine the concentration of amphotericin B in body fluids. The Bactec radiometric system was used to measure CO(2) production by a test strain, Candida albicans MDA 448, in the presence of amphotericin B. After 5-h incubation, drug concentrations as low as 0.2 mug/ml could be detected. The results are comparable to those of the commonly used agar diffusion assay with Paecilomyces varioti.
摘要
开发了一种新的检测方法来测定体液中两性霉素B的浓度。使用Bactec放射测量系统在两性霉素B存在的情况下测量测试菌株白色念珠菌MDA 448产生的CO(2)。孵育5小时后，可检测到低至0.2微克/毫升的药物浓度。结果与常用的用拟青霉的琼脂扩散试验结果相当。
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