Lilis R, Blumberg W E, Fischbein A, Eisinger J, Diamond S, Anderson H A, Selikoff I J
Arch Environ Health. 1977 Nov-Dec;32(6):256-66. doi: 10.1080/00039896.1977.10667292.
A subgroup of workers from a secondary lead smelter was defined to include those with blood lead levels not exceeding 80 microgram/100 ml and with no past history of elevated blood lead. Central nervous system symptoms (tiredness, sleeplessness, irritability, headache) were reported by 55% of the group and muscle and joint pain by 39%. Zinc protoporphyrin (ZPP) levels were elevated in 71% of cases. Low hemoglobin levels (less than 14 gm/100 ml) were found in more than a third of the workers. While BUN and creatinine were mostly in the normal range, there was nevertheless a correlation between ZPP and both BUN and creatinine. Reduced nerve-conduction velocities were present in 25% of the group; this was not significantly different from findings in a control group. The data indicate that a blood level of 80 microgram/100 ml is an inappropriate biological guide in the prevention of lead disease.
一家二次铅冶炼厂的一个工人群体被界定为包括血铅水平不超过80微克/100毫升且既往无血铅升高病史的工人。该群体中55%的人报告有中枢神经系统症状（疲劳、失眠、易怒、头痛），39%的人报告有肌肉和关节疼痛。71%的病例锌原卟啉（ZPP）水平升高。超过三分之一的工人血红蛋白水平较低（低于14克/100毫升）。虽然尿素氮和肌酐大多在正常范围内，但ZPP与尿素氮和肌酐之间仍存在相关性。该群体中25%的人神经传导速度降低；这与对照组的结果无显著差异。数据表明，80微克/100毫升的血铅水平在预防铅中毒方面并非合适的生物学指标。
