Verbruggen G, Veys E M
J Rheumatol. 1979 Sep-Oct;6(5):554-61.
Glycosaminoglycans appear to affect proteoglycan metabolism of fibroblasts, human synovial cells, and chondrocytes under in vitro conditions. The influence of an oversulphated heparinoid (Arteparon) on hyaluronate metabolism of the human synovial lining cell was studied by in vivo experiments on human volunteers. A higher production of better polymerized hyaluronic acid was observed after repeated intraarticular injections of this heparinoid into the knees of 2 osteoarthritic patients. After a single injection a statistically significant rise of synovial fluid hyaluronate concentration was observed over 4 days. A higher molecular weight of this molecule was suspected in view of a significant increase of the anomalous viscosity index 2 and 4 days after intraarticular administration.
在体外条件下，糖胺聚糖似乎会影响成纤维细胞、人滑膜细胞和软骨细胞的蛋白聚糖代谢。通过对人类志愿者进行体内实验，研究了一种过度硫酸化的类肝素（阿特帕龙）对人滑膜衬里细胞透明质酸代谢的影响。在两名骨关节炎患者的膝关节内反复注射这种类肝素后，观察到产生了聚合度更高的透明质酸。单次注射后，在4天内观察到滑液透明质酸浓度有统计学意义的升高。鉴于关节内给药后第2天和第4天异常粘度指数显著增加，怀疑该分子的分子量更高。
