Neuburger N, Levison H, Bryan A C, Kruger K
J Appl Physiol. 1976 Mar;40(3):329-32. doi: 10.1152/jappl.1976.40.3.329.
In the search for more sensitive indicators of airway obstruction Fish et al. (Am. Rev. Respirat. Diseases 109: 700, 1974) have proposed a transit time analysis of the forced expiratory spirogram. In this method the forced vital capacity (FVC) is divided into volumes of air and each volume is assigned a transit time; the nature of the FVC can be described by the transit times' mean, standard deviation, and index of skewness. In a group of 48 healthy nonsmoking subjects between the ages of 9 and 22 yr we found that all three quantities decreased with increasing age. This demonstrates an improvement in the function of the peripheral airways with lung growth. In contrast to the increase in flow rates with lung growth, none of this improved function can be attributed to increased lung volume.
为了寻找气道阻塞更敏感的指标，菲什等人（《美国呼吸与危重症医学杂志》109: 700, 1974）提出了用力呼气肺量图的通过时间分析方法。在该方法中，用力肺活量（FVC）被划分成不同的气量，每个气量都被赋予一个通过时间；FVC的特征可以通过通过时间的均值、标准差和偏度指数来描述。在一组年龄在9至22岁之间的48名健康非吸烟受试者中，我们发现这三个量均随年龄增长而下降。这表明随着肺的生长，外周气道功能有所改善。与随着肺生长流速增加不同，这种功能改善与肺容积增加无关。
