Reisman R E, Light W C, Wypych J I, Arbesman C E
J Allergy Clin Immunol. 1976 Jun;57(6):547-53. doi: 10.1016/0091-6749(76)90005-1.
Specific IgE antibodies and total antibodies reacting with bee venom and yellow jacket venom were measured in sequential serum samples of insect-sensitive individuals. Venom-specific IgE decreased as a function of time and was not significantly affected by treatment with whole body extracts. There was no stimulation of total antibodies reacting with bee venom phospholipase A2 (PLA) following treatment with whole bee body extracts. These studies suggest that as measured by these parameters, whole body insect extracts used in the usual recommended doses are immunologically ineffective antigens.
在对昆虫敏感个体的连续血清样本中，检测了与蜂毒和黄蜂毒液反应的特异性IgE抗体及总抗体。毒液特异性IgE随时间下降，且不受全身提取物治疗的显著影响。用全蜂提取物治疗后，与蜂毒磷脂酶A2（PLA）反应的总抗体未受到刺激。这些研究表明，以这些参数衡量，通常推荐剂量使用的全身昆虫提取物是免疫无效抗原。
