一名多发性硬化症患者大脑中的脑池内病毒样颗粒。
Intracisternal virus-like particles in brain of a multiple sclerosis patient.
作者信息
Tanaka R, Iwasaki Y, Koprowski H
出版信息
J Neurol Sci. 1976 May;28(1):121-6. doi: 10.1016/0022-510x(76)90053-8.
Abstract
Doughnut-shaped particles, 55-65 nm in diameter, were revealed by electron microscopy in the cisterns of the rough endoplasmic reticulum of cells from an active lesion in autopsied brain tissue from a multiple sclerosis patient. The morphology of the particles closely resembled that of coronaviruses.
摘要
在一名多发性硬化症患者尸检脑组织的活动性病变部位的细胞粗面内质网池内，通过电子显微镜观察到了直径为55 - 65纳米的甜甜圈状颗粒。这些颗粒的形态与冠状病毒的形态极为相似。
相似文献
1
Intracisternal virus-like particles in brain of a multiple sclerosis patient.
J Neurol Sci. 1976 May;28(1):121-6. doi: 10.1016/0022-510x(76)90053-8.
2
Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients.
Science. 1980 Aug 22;209(4459):933-4. doi: 10.1126/science.7403860.
3
Human enteric coronaviruses. Brief review.
Arch Virol. 1981;70(4):301-13. doi: 10.1007/BF01320245.
4
The fine structure of the CNS in multiple sclerosis. I. Interpretation of cytoplasmic papovavirus-like and paramyxovirus-like inclusions.
Neuropathol Appl Neurobiol. 1978 Sep-Oct;4(5):343-56. doi: 10.1111/j.1365-2990.1978.tb01347.x.
5
Comparative morphology of measles virus and paramyxovirus-like tubules in multiple sclerosis using ruthenium red stain.
Neuropathol Appl Neurobiol. 1981 Sep-Oct;7(5):411-20. doi: 10.1111/j.1365-2990.1981.tb00242.x.
6
Pseudoviral hollow-cored vesicles in multiple sclerosis brain.
Acta Neuropathol. 1979 Oct;48(1):63-6. doi: 10.1007/BF00691793.
7
Paramyxovirus-like particles associated with acute demyelination in chronic relapsing multiple sclerosis.
Science. 1972 Nov 17;178(4062):760-3. doi: 10.1126/science.178.4062.760.
8
Detection of coronavirus RNA and antigen in multiple sclerosis brain.
Ann Neurol. 1992 May;31(5):525-33. doi: 10.1002/ana.410310511.
9
[Morphology of coronaviruses-- electron microscopic demonstration by negative contrast technic of the transmissible gastroenteritis virus of swine].
Arch Exp Veterinarmed. 1981;35(2):177-86.
10
Antigenic assessment of coronaviruses isolated from patients with multiple sclerosis.
Arch Neurol. 1988 Jun;45(6):629-33. doi: 10.1001/archneur.1988.00520300047017.
引用本文的文献
1
Multiple sclerosis and infection: history, EBV, and the search for mechanism.
Microbiol Mol Biol Rev. 2025 Mar 27;89(1):e0011923. doi: 10.1128/mmbr.00119-23. Epub 2025 Jan 16.
2
Central nervous system manifestations of monogenic autoinflammatory disorders and the neurotropic features of SARS-CoV-2: Drawing the parallels.
Front Pediatr. 2022 Aug 10;10:931179. doi: 10.3389/fped.2022.931179. eCollection 2022.
3
Why do SARS-CoV-2 NSPs rush to the ER?
J Neurol. 2021 Jun;268(6):2013-2022. doi: 10.1007/s00415-020-10197-8. Epub 2020 Sep 1.
4
Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients.
Neurol Sci. 2020 Oct;41(10):2657-2669. doi: 10.1007/s10072-020-04575-3. Epub 2020 Jul 28.
5
Neurobiology of coronaviruses: Potential relevance for COVID-19.
Neurobiol Dis. 2020 Sep;143:105007. doi: 10.1016/j.nbd.2020.105007. Epub 2020 Jul 2.
6
Should we expect neurological symptoms in the SARS-CoV-2 epidemic?
Neurologia (Engl Ed). 2020 Apr;35(3):170-175. doi: 10.1016/j.nrl.2020.03.001. Epub 2020 Apr 6.
7
[New therapies against HCV].
Rev Francoph Lab. 2016 Dec;2016(487):25-33. doi: 10.1016/S1773-035X(16)30369-0. Epub 2016 Dec 26.
8
Neuroinvasion by human respiratory coronaviruses.
J Virol. 2000 Oct;74(19):8913-21. doi: 10.1128/jvi.74.19.8913-8921.2000.
9
Mouse hepatitis virus strain JHM infects a human hepatocellular carcinoma cell line.
Virology. 1999 Nov 25;264(2):398-409. doi: 10.1006/viro.1999.9984.
10
Involvement of aminopeptidase N (CD13) in infection of human neural cells by human coronavirus 229E.
J Virol. 1998 Aug;72(8):6511-9. doi: 10.1128/JVI.72.8.6511-6519.1998.
本文引用的文献
1
A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN : II. PATHOLOGY.
J Exp Med. 1949 Aug 31;90(3):195-212. doi: 10.1084/jem.90.3.195.
2
Measles antibodies in multiple sclerosis.
Proc Soc Exp Biol Med. 1962 Dec;111:562-6. doi: 10.3181/00379727-111-27855.
3
Suggestions for the classification of oncogenic RNA viruses.
J Natl Cancer Inst. 1966 Sep;37(3):395-7. doi: 10.1093/jnci/37.3.395.
4
Paramyxovirus-like particles associated with acute demyelination in chronic relapsing multiple sclerosis.
Science. 1972 Nov 17;178(4062):760-3. doi: 10.1126/science.178.4062.760.
5
Mechanism of demyelination in JHM virus encephalomyelitis. Electron microscopic studies.
Acta Neuropathol. 1973 Mar 30;24(1):76-85. doi: 10.1007/BF00691421.
6
Tubular aggregates in endoplasmic reticulum: evidence against their viral nature.
J Ultrastruct Res. 1972 Nov;41(3):270-6. doi: 10.1016/s0022-5320(72)90069-x.
7
Measles virus antibodies in multiple sclerosis. Comparison of antibody titers in cerebrospinal fluid and serum.
Arch Neurol. 1974 Apr;30(4):285-92. doi: 10.1001/archneur.1974.00490340013002.
8
Acute multiple sclerosis: electron-microscopic evidence for and against a viral agent in the plaques.
Lancet. 1973 Dec 22;2(7843):1408-11. doi: 10.1016/s0140-6736(73)92801-8.
9
Fusion of cultured multiple-sclerosis brain cells with indicator cells: presence of nucleocapsids and virions and isolation of parainfluenza-type virus.
Lancet. 1972 Jul 1;2(7766):1-5. doi: 10.1016/s0140-6736(72)91273-1.
10
Ultrastructural studies of perivascular cuffing cells in multiple sclerosis brain.
Am J Pathol. 1975 Dec;81(3):467-78.
Zotero 插件