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一名多发性硬化症患者大脑中的脑池内病毒样颗粒。

Intracisternal virus-like particles in brain of a multiple sclerosis patient.

作者信息

Tanaka R, Iwasaki Y, Koprowski H

出版信息

J Neurol Sci. 1976 May;28(1):121-6. doi: 10.1016/0022-510x(76)90053-8.

DOI:10.1016/0022-510x(76)90053-8
PMID:932771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7118424/
Abstract

Doughnut-shaped particles, 55-65 nm in diameter, were revealed by electron microscopy in the cisterns of the rough endoplasmic reticulum of cells from an active lesion in autopsied brain tissue from a multiple sclerosis patient. The morphology of the particles closely resembled that of coronaviruses.

摘要

在一名多发性硬化症患者尸检脑组织的活动性病变部位的细胞粗面内质网池内，通过电子显微镜观察到了直径为55 - 65纳米的甜甜圈状颗粒。这些颗粒的形态与冠状病毒的形态极为相似。

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Science. 1972 Nov 17;178(4062):760-3. doi: 10.1126/science.178.4062.760.
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Measles virus antibodies in multiple sclerosis. Comparison of antibody titers in cerebrospinal fluid and serum.多发性硬化症中的麻疹病毒抗体。脑脊液和血清中抗体滴度的比较。
Arch Neurol. 1974 Apr;30(4):285-92. doi: 10.1001/archneur.1974.00490340013002.
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Acute multiple sclerosis: electron-microscopic evidence for and against a viral agent in the plaques.
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Ultrastructural studies of perivascular cuffing cells in multiple sclerosis brain.多发性硬化症脑内血管周围套细胞的超微结构研究
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