Rahman S, Fukamiya N, Okano M, Tagahara K, Lee K H
Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1527-9. doi: 10.1248/cpb.45.1527.
In vitro evaluation of anti-tuberculosis activity was conducted for fifty-six quassinoids isolated in our laboratory from Simaroubaceous plants, Ailanthus altissima (= Aa, 10 compounds), Brucea antidysenterica (= Ba, 16 compounds), Picrasma ailanthoides (= Pa, 14 compounds), and Brucea javanica (= Bj, 16 compounds). Of the compounds tested, shinjulactone K (1), ailanthone (2), shinjudilactone (3), and dehydrobruceantin (4) were the most potent. Although the activities were very low (0-19%), the resulting data provided a picture of structure-activity relationships.
对我们实验室从苦木科植物臭椿（=Aa，10种化合物）、鸦胆子（=Ba，16种化合物）、苦木（=Pa，14种化合物）和鸦胆子（=Bj，16种化合物）中分离得到的56种苦木素类化合物进行了抗结核活性的体外评估。在所测试的化合物中，新朱内酯K（1）、臭椿酮（2）、新朱地内酯（3）和脱氢鸦胆子苦素（4）活性最强。尽管活性非常低（0 - 19%），但所得数据提供了构效关系的情况。
