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Antimicrob Agents Chemother. 1997 Oct;41(10):2317-9. doi: 10.1128/AAC.41.10.2317.
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In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia.在印度尼西亚巴布亚，氯喹对间日疟原虫和卵形疟原虫的体内和体外疗效。
Antimicrob Agents Chemother. 2011 Jan;55(1):197-202. doi: 10.1128/AAC.01122-10. Epub 2010 Oct 11.

本文引用的文献

1
Pyronaridine: A new antimalarial drug.咯萘啶：一种新型抗疟药物。
Parasitol Today. 1991 Nov;7(11):310-3. doi: 10.1016/0169-4758(91)90267-r.
2
Status of antimalarial drugs under development.正在研发的抗疟药物的现状。
Bull World Health Organ. 1995;73(5):565-71.
3
In vitro activity of antimalarials against clinical isolates of Plasmodium falciparum in Yaounde, Cameroon.抗疟药对喀麦隆雅温得恶性疟原虫临床分离株的体外活性。
Am J Trop Med Hyg. 1996 Sep;55(3):254-8. doi: 10.4269/ajtmh.1996.55.254.
4
Clinical study of pyronaridine for the treatment of acute uncomplicated falciparum malaria in Thailand.咯萘啶治疗泰国急性非复杂性恶性疟的临床研究。
Am J Trop Med Hyg. 1996 Feb;54(2):205-9. doi: 10.4269/ajtmh.1996.54.205.
5
Randomised trial of pyronaridine versus chloroquine for acute uncomplicated falciparum malaria in Africa.非洲地区咯萘啶与氯喹治疗急性非复杂性恶性疟随机试验
Lancet. 1996 Jan 6;347(8993):24-8. doi: 10.1016/s0140-6736(96)91558-5.
6
Short-term in vitro culture of Plasmodium vivax and P. ovale for drug-susceptibility testing.
Parasitol Res. 1994;80(3):262-4. doi: 10.1007/BF00932686.
7
Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine.用氯喹和伯氨喹或卤泛群治疗抗氯喹间日疟原虫感染
J Infect Dis. 1995 Jun;171(6):1678-82. doi: 10.1093/infdis/171.6.1678.
8
First report of in vitro susceptibility of Plasmodium malariae Thai isolates to chloroquine.
Southeast Asian J Trop Med Public Health. 1994 Dec;25(4):784-7.
9
Adaptations of the Saker-Solomons test: simple, reliable colorimetric field assays for chloroquine and its metabolites in urine.萨克-所罗门试验的改良：用于检测尿液中氯喹及其代谢物的简单、可靠的比色现场检测法。
Bull World Health Organ. 1989;67(3):295-300.
10
Studies on a new antimalarial compound: pyronaridine.新型抗疟化合物：咯萘啶的研究。
Trans R Soc Trop Med Hyg. 1992 Jan-Feb;86(1):7-10. doi: 10.1016/0035-9203(92)90414-8.

咯萘啶用于治疗卵形疟原虫和三日疟原虫感染。

Pyronaridine for treatment of Plasmodium ovale and Plasmodium malariae infections.

作者信息

Ringwald P, Bickii J, Same-Ekobo A, Basco L K

机构信息

Institut Français de Recherche Scientifique pour le Développement en Coopération (ORSTOM), Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale, Yaoundé, Cameroon.

出版信息

Antimicrob Agents Chemother. 1997 Oct;41(10):2317-9. doi: 10.1128/AAC.41.10.2317.

DOI:10.1128/AAC.41.10.2317
PMID:9333075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC164120/
Abstract

The clinical efficacy of oral pyronaridine was assessed in 22 symptomatic Cameroonian patients infected with Plasmodium ovale or Plasmodium malariae. All patients were cured on or before day 4. In vitro drug assays confirmed the sensitivity of P. ovale and P. malariae isolates to chloroquine and pyronaridine.

摘要

对22名感染卵形疟原虫或三日疟原虫的喀麦隆有症状患者评估了口服咯萘啶的临床疗效。所有患者均在第4天或之前治愈。体外药物试验证实卵形疟原虫和三日疟原虫分离株对氯喹和咯萘啶敏感。