Slawienski M J, Mauldin G E, Mauldin G N, Patnaik A K
Department of Surgery, The Animal Medical Center, New York, NY 10021, USA.
J Am Vet Med Assoc. 1997 Oct 1;211(7):878-81.
To evaluate a group of cats with malignant colonic neoplasia and to identify factors related to survival time.
Retrospective study.
46 cats with malignant colonic neoplasia.
Information on signalment, diagnostic findings, histopathologic diagnosis, surgical procedure performed, identification of nodal metastasis at surgery, type of chemotherapy administered, and survival time was obtained from the medical record of each cat. A diagnosis of malignant colonic neoplasia had been established by histologic examination of endoscopic biopsy specimens (3 cats), biopsy specimens obtained during laparotomy (38), or necropsy specimens (5).
Mean age of cats was 12.5 years (range, 6 to 18 years). Ultrasonography was useful 84% of the time in localizing the mass to the intestine. Three cats had endoscopic biopsy, 9 had incisional biopsy, 21 had mass resection, and 8 had subtotal colectomy performed. Histopathologic diagnoses included adenocarcinoma (21 cats), lymphoma (19), mast cell tumor (4), and neuroendocrine carcinoma (2).
Obtaining clean margins at surgery seems to increase survival time in cats with malignant colonic neoplasia. Metastasis at the time of surgery decreases survival time. Data from this study indicate that the survival time of certain cats with colonic lymphoma may not be affected by chemotherapy. Cats with an unidentified colonic mass should receive a subtotal colectomy to increase survival time. Cats with colonic adenocarcinoma should receive a subtotal colectomy with consideration of doxorubicin administration to increase survival time.
评估一组患有恶性结肠肿瘤的猫，并确定与生存时间相关的因素。
回顾性研究。
46只患有恶性结肠肿瘤的猫。
从每只猫的病历中获取有关信号、诊断结果、组织病理学诊断、所实施的外科手术、手术时淋巴结转移的识别、所给予的化疗类型以及生存时间的信息。通过对内镜活检标本（3只猫）、剖腹术期间获取的活检标本（38只）或尸检标本（5只）进行组织学检查，已确诊为恶性结肠肿瘤。
猫的平均年龄为12.5岁（范围为6至18岁）。超声检查在84%的时间里有助于将肿块定位到肠道。3只猫进行了内镜活检，9只进行了切开活检，21只进行了肿块切除，8只进行了结肠次全切除术。组织病理学诊断包括腺癌（21只猫）、淋巴瘤（19只）、肥大细胞瘤（4只）和神经内分泌癌（2只）。
手术时获得切缘阴性似乎可增加患有恶性结肠肿瘤的猫的生存时间。手术时发生转移会缩短生存时间。本研究数据表明，某些患有结肠淋巴瘤的猫的生存时间可能不受化疗影响。患有不明结肠肿块的猫应接受结肠次全切除术以延长生存时间。患有结肠腺癌的猫应接受结肠次全切除术并考虑给予阿霉素以延长生存时间。
