Reymão M S, Cury P M, Lichtenfels A J, Lemos M, Battlehner C N, Conceição G M, Capelozzi V L, Montes G S, Júnior M F, Martins M A, Böhm G M, Saldiva P H
Laboratório de Poluição Atmosférica Experimental, Faculdade de Medicina, Universidade de São Paulo, Brazil.
Environ Res. 1997;74(2):150-8. doi: 10.1006/enrs.1997.3740.
This paper investigates the association between air pollution and lung neoplasia in an animal model. The experimental exposures were done in two locations with different air pollution profiles: a polluted area (downtown São Paulo) and a "clean" environment (Atibaia). Swiss mice were employed and urethane (3 g/kg) was used as carcinogenic substance. Two experiments were performed: Experiment I was designed to verify whether air pollution acts as initiator and/or promoter of lung cancer, using 300 mice; Experiment II employed 250 animals and aimed to verify if the effects of air pollution on the development of lung tumors was dose dependent. A significant effect of air pollution in augmenting lung carcinogenecity induced by urethane was observed. This effect was shown to be dose-dependent and reproducible on two different occasions. In addition, morphometric studies revealed that pollution may influence tumor phenotype. These results support the hypothesis that air pollution plays a significant role in the development of lung tumors.
本文在动物模型中研究了空气污染与肺肿瘤之间的关联。实验暴露在两个具有不同空气污染特征的地点进行：一个污染区域（圣保罗市中心）和一个“清洁”环境（阿蒂巴亚）。使用了瑞士小鼠，并将氨基甲酸乙酯（3克/千克）用作致癌物质。进行了两项实验：实验I使用300只小鼠，旨在验证空气污染是否作为肺癌的启动剂和/或促进剂；实验II使用250只动物，旨在验证空气污染对肺肿瘤发展的影响是否呈剂量依赖性。观察到空气污染对氨基甲酸乙酯诱导的肺癌发生有显著影响。这种影响在两个不同的场合被证明是剂量依赖性的且可重复的。此外，形态计量学研究表明污染可能影响肿瘤表型。这些结果支持了空气污染在肺肿瘤发展中起重要作用这一假设。
