Batura-Gabryel H, Wieczorek U, Mlynarczyk W
Kliniki Pneumonologii Instytutu Chorób Wewnetrznych A. M. w Poznaniu.
Pneumonol Alergol Pol. 1997;65(5-6):355-9.
The aim of the study was the estimation of in vitro susceptibility to antifungal agents of yeast isolated from sputum of 70 respiratory diseases patients using the disc-diffusion method-antimycogram. The following agents were tested: amphotericin B, 5-fluorocytosine, nystatin, ketoconazole, fluconazole. Only Candida strains were isolated from sputum, 82% of them were Candida albicans. We noted differences in susceptibility to antimycotics of Candida strains. The best antimycotic in vitro was 5-fluorocytosine. 54% of isolated Candida strains were resistant to 1 or more antimycotics.
本研究的目的是采用纸片扩散法(抗真菌药敏谱)评估从70例呼吸道疾病患者痰液中分离出的酵母对抗真菌药物的体外敏感性。所检测的药物如下:两性霉素B、5-氟胞嘧啶、制霉菌素、酮康唑、氟康唑。痰液中仅分离出念珠菌菌株,其中82%为白色念珠菌。我们注意到念珠菌菌株对抗真菌药物的敏感性存在差异。体外效果最佳的抗真菌药物是5-氟胞嘧啶。54%的分离出的念珠菌菌株对1种或更多种抗真菌药物耐药。