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[从患有各种呼吸道疾病的患者中分离出的念珠菌菌株对抗真菌剂的体外敏感性]

[In vitro susceptibility to antifungal agents of Candida strains isolated from patients with various diseases of the respiratory tract].

作者信息

Batura-Gabryel H, Wieczorek U, Mlynarczyk W

机构信息

Kliniki Pneumonologii Instytutu Chorób Wewnetrznych A. M. w Poznaniu.

出版信息

Pneumonol Alergol Pol. 1997;65(5-6):355-9.

PMID:9340063
Abstract

The aim of the study was the estimation of in vitro susceptibility to antifungal agents of yeast isolated from sputum of 70 respiratory diseases patients using the disc-diffusion method-antimycogram. The following agents were tested: amphotericin B, 5-fluorocytosine, nystatin, ketoconazole, fluconazole. Only Candida strains were isolated from sputum, 82% of them were Candida albicans. We noted differences in susceptibility to antimycotics of Candida strains. The best antimycotic in vitro was 5-fluorocytosine. 54% of isolated Candida strains were resistant to 1 or more antimycotics.

摘要

本研究的目的是采用纸片扩散法(抗真菌药敏谱)评估从70例呼吸道疾病患者痰液中分离出的酵母对抗真菌药物的体外敏感性。所检测的药物如下:两性霉素B、5-氟胞嘧啶、制霉菌素、酮康唑、氟康唑。痰液中仅分离出念珠菌菌株,其中82%为白色念珠菌。我们注意到念珠菌菌株对抗真菌药物的敏感性存在差异。体外效果最佳的抗真菌药物是5-氟胞嘧啶。54%的分离出的念珠菌菌株对1种或更多种抗真菌药物耐药。

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