Ravelli G P, Stein Z A, Susser M W
N Engl J Med. 1976 Aug 12;295(7):349-53. doi: 10.1056/NEJM197608122950701.
In a historical cohort study of 300,000 19-year-old men exposed to the Dutch famine of 1944-45 and examined at military induction, we tested the hypothesis that prenatal and early postnatal nutrition determines subsequent obesity. Outcomes were opposite depending on the time of exposure. During the last trimester of pregnancy and the first months of life, exposure produced significantly lower obesity rates (P less than 0.005). This result is consistent with the inference that nutritional deprivation affected a critical period of development for adipose-tissue cellularity. During the first half of pregnancy, however, exposure resulted in significantly higher obesity rates (P less than 0.0005). This observation is consistent with the inference that nutritional deprivation affected the differentiation of hypothalamic centers regulating food intake and growth, and that subsequent increased food availability produced an accumulation of excess fat in an organism growing to its predetermined maximum size.
在一项针对30万名19岁男性的历史性队列研究中，这些男性在1944 - 1945年经历了荷兰饥荒，并在入伍体检时接受了检查。我们检验了产前和产后早期营养决定后续肥胖的假设。根据暴露时间的不同，结果相反。在妊娠晚期和生命的头几个月，暴露导致肥胖率显著降低（P小于0.005）。这一结果与营养剥夺影响脂肪组织细胞发育关键期的推断一致。然而，在妊娠前半期，暴露导致肥胖率显著升高（P小于0.0005）。这一观察结果与营养剥夺影响调节食物摄入和生长的下丘脑中心分化的推断一致，并且随后食物供应增加导致在生长到其预定最大尺寸的生物体中积累了过多脂肪。
