Carrick F R
Division of Post-Doctoral Education, Logan College of Chiropractic, Chesterfield, MO, USA.
J Manipulative Physiol Ther. 1997 Oct;20(8):529-45.
To ascertain whether manipulation of the cervical spine is associated with changes in brain function.
Physiological cortical maps were used as an integer of brain activity before and after manipulation of the cervical spine in a large (500 subjects), double-blind controlled study.
Institutional clinic Participants: Adult volunteers.
Five hundred subjects were divided into six comparative groups and underwent specific manipulation of the second cervical motion segment. Blinded examiners obtained reproducible pre- and postmanipulative cortical maps, which were subjected to statistical analysis.
Brain activity was demonstrated by reproducible circumferential measurements of cortical hemispheric blind-spot maps before and after manipulation of the second cervical motion segment. Twelve null hypotheses were developed. The critical alpha level was adjusted in accordance with Bonferroni's theorem to .004 (.05 divided by 12) to reduce the likelihood of wrongly rejecting the null hypothesis (i.e., committing a Type I error).
Manipulation of the cervical spine on the side of an enlarged cortical map is associated with increased contralateral cortical activity with strong statistical significance (p < .001). Manipulation of the cervical spine on the side opposite an enlarged cortical map is associated with decreased cortical activity with strong statistical significance (p < .001). Manipulation of the cervical spine was specific for changes in only one cortical hemisphere with strong statistical significance (p < .001).
Accurate reproducible maps of cortical responses can be used to measure the neurological consequences of spinal joint manipulation. Cervical manipulation activates specific neurological pathways. Manipulation of the cervical spine may be associated with an increase or a decrease in brain function depending upon the side of the manipulation and the cortical hemisphericity of a patient.
确定颈椎推拿是否与脑功能变化相关。
在一项大型（500名受试者）双盲对照研究中，使用生理皮质图谱作为颈椎推拿前后脑活动的指标。
机构诊所 参与者：成年志愿者。
500名受试者被分为六个比较组，并接受第二颈椎活动节段的特定推拿。不知情的检查者获取可重复的推拿前和推拿后皮质图谱，并进行统计分析。
通过对第二颈椎活动节段推拿前后皮质半球盲点图谱进行可重复的圆周测量来证明脑活动。提出了12个无效假设。根据邦费罗尼定理将临界α水平调整为0.004（0.05除以12），以降低错误拒绝无效假设（即犯I型错误）的可能性。
在皮质图谱扩大一侧的颈椎推拿与对侧皮质活动增加相关，具有很强的统计学意义（p < 0.001）。在皮质图谱扩大一侧对侧的颈椎推拿与皮质活动减少相关，具有很强的统计学意义（p < 0.001）。颈椎推拿仅对一个皮质半球的变化具有特异性，具有很强的统计学意义（p < 0.001）。
皮质反应的准确可重复图谱可用于测量脊柱关节推拿的神经学后果。颈椎推拿激活特定的神经通路。颈椎推拿可能与脑功能的增加或减少相关，这取决于推拿的一侧和患者的皮质半球性。
