所选三萜类化合物对慢性皮肤炎症的影响。
Effect of selected triterpenoids on chronic dermal inflammation.
作者信息
Máñez S, Recio M C, Giner R M, Ríos J L
机构信息
Departament de Farmacologia, Universitat de València, Spain.
出版信息
Eur J Pharmacol. 1997 Sep 3;334(1):103-5. doi: 10.1016/s0014-2999(97)01187-4.
PMID:9346335
Abstract
The activity of four natural triterpenoids on a 12-O-tetradecanoylphorbol-13-acetate multiple-dose model of skin chronic inflammation was studied. Erythrodiol and ursolic acid were significantly effective. The most important features concerning structure-activity relationship and previous data on the effect of these triterpenoids on other inflammatory conditions are discussed.
摘要
研究了四种天然三萜类化合物对12-O-十四酰佛波醇-13-乙酸酯多剂量皮肤慢性炎症模型的活性。羽扇豆醇和熊果酸具有显著疗效。讨论了有关构效关系的最重要特征以及这些三萜类化合物对其他炎症状况影响的先前数据。
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