Ferguson J E, Andrew S M, Jones C J, August P J
Dermatology Centre, Hope Hospital, Salford, U.K.
Br J Dermatol. 1997 Sep;137(3):405-10.
The Nd:YAG laser effectively removes or lightens amateur and professional tattoos. The biomechanics of the removal of tattoo particles at the cellular level are incompletely understood. We examined biopsies obtained from 35 amateur and professional tattoos (including coloured tattoos), treated on three or more occasions with the Nd:YAG laser. Biopsies taken immediately after laser treatment showed vacuolation with complete clearance of tattoo particles in the most superficial layers of the dermis, as assessed by light and electron microscopy. We propose that the 'disappearance' of the tattoo particle arises from the formation of atomic species and gaseous products, which are rapidly dissolved in the extracellular fluid. Residual fragmented particles that are commonly found in the mid- and lower dermis are rephagocytosed. The interaction between the Nd:YAG laser and black tattoo particles at 1064 nm, and red tattoo particles at 532 nm, appears to be specific, as there was little evidence of thermal damage to adjacent cells or stromal collagen.
钕钇铝石榴石激光能有效去除或淡化业余和专业纹身。纹身颗粒在细胞水平上被去除的生物力学机制尚未完全明了。我们检查了35例业余和专业纹身（包括彩色纹身）的活检样本，这些纹身接受了三次或更多次钕钇铝石榴石激光治疗。激光治疗后立即进行的活检显示，通过光学显微镜和电子显微镜评估，真皮最表层出现空泡化，纹身颗粒完全清除。我们认为纹身颗粒的“消失”源于原子物种和气态产物的形成，它们迅速溶解于细胞外液中。在真皮中层和下层常见的残留破碎颗粒会被重新吞噬。钕钇铝石榴石激光与1064纳米的黑色纹身颗粒以及532纳米的红色纹身颗粒之间的相互作用似乎具有特异性，因为几乎没有证据表明相邻细胞或间质胶原受到热损伤。
