Si N V, Grytter C, Vy N N, Hue N B, Pedersen F K
Paediatric Hospital No.1, Ho Chi Minh City, Vietnam.
Acta Paediatr. 1997 Oct;86(10):1052-5. doi: 10.1111/j.1651-2227.1997.tb14805.x.
We carried out a randomized, placebo-controlled, double-blinded trial to evaluate the effect on morbidity of high dose oral vitamin A, given on hospital admission to 592 children aged 1-59 months with moderate and severe pneumonia. Severely underweight children were not included, but 45% were moderately underweight. The vitamin A and placebo groups were comparable in baseline characteristics. Four patients died. Among all of the surviving children, no differences were found regarding mean time for normalization of fever, respiratory rate and time of hospitalization. Stratification for moderate malnutrition, degree of pneumonia, age and sex revealed moderately malnourished vitamin A-supplemented children to have a shorter time of hospitalization (p = 0.04), due to an effect in females aged > 12 months (p = 0.02) and females with very severe pneumonia (p = 0.048). This study indicates that, in developing countries like Vietnam, supplementation with vitamin A in children with pneumonia could shorten the recovery rate in the ones that are undernourished, especially females > 1 y old.
我们开展了一项随机、安慰剂对照、双盲试验，以评估入院时给予592名1至59个月患有中度和重度肺炎的儿童高剂量口服维生素A对发病率的影响。严重体重不足的儿童未纳入，但45%为中度体重不足。维生素A组和安慰剂组的基线特征具有可比性。4名患者死亡。在所有存活儿童中，发热、呼吸频率恢复正常的平均时间以及住院时间均无差异。按中度营养不良、肺炎程度、年龄和性别分层显示，补充维生素A的中度营养不良儿童住院时间较短（p = 0.04），这是由于12个月以上女性（p = 0.02）和患有极重度肺炎的女性（p = 0.048）有此效果。这项研究表明，在越南这样的发展中国家，肺炎儿童补充维生素A可缩短营养不良儿童尤其是1岁以上女性的康复时间。
