在一项单次被动回避任务中，小鼠体内环己酰亚胺和6-羟基多巴胺遗忘效应的比较。
Comparison in mice of the amnestic effects of cycloheximide and 6-hydroxydopamine in a one-trial passive avoidance task.
作者信息
Rainbow T C, Adler J E, Flexner L B
出版信息
Pharmacol Biochem Behav. 1976 Mar;4(3):347-9. doi: 10.1016/0091-3057(76)90254-9.
PMID:935206
Abstract
To test further the hypothesis that cycloheximide (CXM)-induced amnesia is due in part to its effects on the central adrenergic system, a comparison was made in mice of the effects of the antibiotic and of 6-hydroxydopamine (6-OHDA) on memory of a one-trial passive avoidance task. Both drugs produced anmesia 24 hr after training but unlike CXM, 6-OHDA had no effect on memory 20 min after training.
摘要
为了进一步验证环己酰亚胺（CXM）诱导的失忆部分归因于其对中枢肾上腺素能系统的作用这一假说，在小鼠中比较了该抗生素与6-羟基多巴胺（6-OHDA）对一次性被动回避任务记忆的影响。两种药物在训练后24小时均产生了失忆，但与CXM不同的是，6-OHDA在训练后20分钟对记忆没有影响。
Zotero 插件