Sala A, Penacino G, Corach D
Servicio de Huellas Digitales Genéticas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Hum Biol. 1997 Dec;69(6):777-83.
VNTR loci provide a wealth of information for human genetic research, ranging from gene mapping to paternity testing and forensic identification. In this study we report the construction, validation, and analysis of the first local genetic database for VNTR markers for Argentina. A sample of the metropolitan population of Buenos Aires was typed by means of six VNTR systems. Allele frequencies and expected heterozygosity were calculated. The sample set was further tested for departures from Hardy-Weinberg equilibrium and power of exclusion. Allele frequency distributions are compatible with previously reported data on Caucasian populations, and no departures from Hardy-Weinberg equilibrium were detected.
可变数目串联重复序列(VNTR)位点为人类遗传学研究提供了丰富的信息,从基因定位到亲子鉴定以及法医鉴定等。在本研究中,我们报告了阿根廷首个VNTR标记局部遗传数据库的构建、验证及分析情况。通过六个VNTR系统对布宜诺斯艾利斯市城区人口样本进行了分型。计算了等位基因频率和预期杂合度。对样本集进一步检测了其是否偏离哈迪-温伯格平衡以及排除能力。等位基因频率分布与先前报道的高加索人群数据相符,未检测到偏离哈迪-温伯格平衡的情况。