配体结合亲和力和特异性的分子与生物学限制因素。
Molecular and biological constraints on ligand-binding affinity and specificity.
作者信息
Szwajkajzer D, Carey J
机构信息
Princeton University, Department of Chemistry, NJ 08544, USA.
出版信息
Biopolymers. 1997;44(2):181-98. doi: 10.1002/(SICI)1097-0282(1997)44:2<181::AID-BIP5>3.0.CO;2-R.
Abstract
Interactions between biological macromolecules have characteristic values of affinity and specificity that are set according to the biological function that is served by the interaction in the organism. Here we examine the molecular mechanisms that are used to achieve the required values of affinity and specificity in various biological systems.
摘要
生物大分子之间的相互作用具有亲和力和特异性的特征值，这些特征值是根据该相互作用在生物体中所发挥的生物学功能来设定的。在此，我们研究了在各种生物系统中用于实现所需亲和力和特异性值的分子机制。
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