Kalter S S, Heberling R L, Cooke A W, Barry J D, Tian P Y, Northam W J
Virus Reference Laboratory, Inc. (VRL), San Antonio, Texas 78229, USA.
Lab Anim Sci. 1997 Oct;47(5):461-7.
Approximately 53,000 serologic tests and viral isolation studies were performed on 1,700 nonhuman primate specimens for evidence of past and/or current viral infection. Information, other than the requested test, generally was not provided with the specimen. This lack of information does not permit any attempt at interpretation of results. Requested testing included a large number of diverse viral agents in approximately 40 primate species. The resulting data are in keeping with those of previous studies and offer an insight into the needs of colony management, as well as some general information on the overall frequency of infection with the indicated viruses. Inasmuch as the results represent testing of single specimens, they are not to be construed as "diagnostic," and simply indicate past infection as represented by the presence of antibody in the test animal. Viral isolation results are listed, and the number of positive results versus the number of animals tested emphasizes the limitations of the procedure. Investigations such as these continue to assist in the maintenance of healthy nonhuman primate colonies. This information also supports continued use of nonhuman primates for research in human viral infections and may be helpful in terms of animal selection for use in xenotransplants.
对1700份非人灵长类动物标本进行了约53000次血清学检测和病毒分离研究，以寻找过去和/或当前病毒感染的证据。除了所要求的检测外，标本通常未附带其他信息。这种信息缺失使得无法对结果进行任何解读。所要求的检测包括约40种灵长类动物中的大量不同病毒病原体。所得数据与先前研究的数据一致，为群体管理需求提供了见解，以及关于所指示病毒总体感染频率的一些一般信息。由于结果代表对单个标本的检测，它们不应被视为“诊断性的”，而仅表明受试动物体内存在抗体所代表的过去感染。列出了病毒分离结果，阳性结果数量与受试动物数量的对比突出了该程序的局限性。此类调查继续有助于维持健康的非人灵长类动物群体。这些信息也支持继续将非人灵长类动物用于人类病毒感染研究，并且在选择用于异种移植的动物方面可能有所帮助。
