具有硫代烯丙基的有机硫化合物对培养的大鼠海马神经元的神经营养活性。
Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons.
作者信息
Moriguchi T, Matsuura H, Kodera Y, Itakura Y, Katsuki H, Saito H, Nishiyama N
机构信息
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
出版信息
Neurochem Res. 1997 Dec;22(12):1449-52. doi: 10.1023/a:1021946210399.
Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAC), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors.
在大蒜提取物中发现的几种有机硫化合物可促进大鼠海马神经元在体外的存活。通过结构-活性关系分析，这些化合物中的硫代烯丙基基团对于神经营养活性的表现至关重要。S-烯丙基-L-半胱氨酸（SAC）是大蒜提取物中具有硫代烯丙基基团的有机硫化合物之一，它也促进了培养神经元的轴突分支。这些结果表明，硫代烯丙基化合物构成了一类独特的神经营养因子。
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