葡萄糖激酶位于胰腺D细胞的分泌颗粒中。
Glucokinase is located in secretory granules of pancreatic D-cells.
作者信息
Toyoda Y, Yoshie S, Fujita T, Ito Y, Nonogaki T, Miwa I
机构信息
Department of Clinical Biochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
出版信息
FEBS Lett. 1997 Oct 6;415(3):281-4. doi: 10.1016/s0014-5793(97)01139-3.
We immunohistochemically examined the distribution of glucokinase in rat pancreatic islets. Glucokinase immunoreactivity under light microscopy was detected in the cytoplasm of somatostatin cells as well as in that of insulin cells. No specific immunoreactivity was detected in glucagon and pancreatic polypeptide cells. In somatostatin cells, glucokinase immunoreactivity was located by electron microscopy exclusively within secretory granules.
我们通过免疫组织化学方法检测了大鼠胰岛中葡萄糖激酶的分布。在光学显微镜下，在生长抑素细胞和胰岛素细胞的细胞质中均检测到葡萄糖激酶免疫反应性。在胰高血糖素细胞和胰多肽细胞中未检测到特异性免疫反应性。在生长抑素细胞中，通过电子显微镜观察发现葡萄糖激酶免疫反应性仅位于分泌颗粒内。
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