原位DNA交联作为染色质结构的一种探针
Cross-linking of DNA in situ as a probe for chromatin structure.
作者信息
Hanson C V, Shen C K, Hearst J E
出版信息
Science. 1976 Jul 2;193(4247):62-4. doi: 10.1126/science.935855.
PMID:935855
Abstract
The photochemical cross-linking of DNA in situ in chromatin is blocked over short intervals. Electron microscopy of DNA cross-linked in chromatin reveals the lengths of protected regions and provides a map of their sites along the DNA. Protected regions occur most frequently in tandem and have a basic length of 160 to 200 base pairs.
摘要
染色质中DNA的原位光化学交联在短时间间隔内被阻断。对染色质中交联的DNA进行电子显微镜观察可揭示受保护区域的长度，并提供其沿DNA的位点图谱。受保护区域最常串联出现，基本长度为160至200个碱基对。
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