Hennekens C H, Saslaw M S
South Med J. 1976 Jun;69(6):759-61, 763. doi: 10.1097/00007611-197606000-00030.
During a 16-week period in late 1969, 11 cases of diphtheria (three fatal) were reported from Miami, Dade County, Florida. For each of ten previous years, two cases at most had been reported. All patients resided in a predominantly black, low socioeconomic community within the 7-square-mile Model City area. Nine patients had positive cultures for toxigenic Corynebacterium diphtheriae, mitis strain. None of the 11 patients or 22 culture-positive household contacts had been vaccinated against diphtheria. During the outbreak, one dose of diphtheria-tetanus-pertussis vaccine or tetanus-diphtheria toxoid was given to more than 90,000 residents of Model City (95%) and to more than 200,000 residents of Dade County (16%). A state law was passed in June 1971 requiring all children to be vaccinated before entering school. No subsequent cases of diphtheria were reported in the ensuing five-year period. The Miami experience suggests that prompt mass vaccination will abort the spread of epidemic diphtheria and emphasizes the need for routine vaccination to minimize morbidity and mortality.
1969年末的16周内，佛罗里达州戴德县迈阿密报告了11例白喉病例（3例死亡）。在之前的十年里，每年最多报告两例。所有患者都居住在7平方英里模范城区内一个以黑人为主、社会经济地位较低的社区。9例患者的产毒白喉棒状杆菌轻型菌株培养呈阳性。11例患者及22例培养阳性的家庭接触者均未接种过白喉疫苗。疫情爆发期间，超过90000名模范城区居民（95%）和超过200000名戴德县居民（16%）接种了一剂白喉-破伤风-百日咳疫苗或破伤风-白喉类毒素。1971年6月通过了一项州法律，要求所有儿童在入学前接种疫苗。在随后的五年里，没有再报告白喉病例。迈阿密的经验表明，迅速进行大规模疫苗接种将阻止流行性白喉的传播，并强调了进行常规疫苗接种以降低发病率和死亡率的必要性。
