Zhang Y J, Fracasso C, Fiore J R, Björndal A, Angarano G, Gringeri A, Fenyö E M
Microbiology and Tumorbiology Centre, Karolinska Institute, Stockholm, Sweden.
J Infect Dis. 1997 Nov;176(5):1180-7. doi: 10.1086/514111.
Neutralizing activity against primary human immunodeficiency virus type 1 (HIV-1) isolates from 17 persons who were long-term disease nonprogressors (LTNPs) and 13 persons who were fast progressors (FPs) was compared. Sera from LTNPs showed higher neutralizing activity both in titer and in host spectrum than did sera from FPs. However, LTNP sera had limited neutralizing activity against HIV-1 subtypes from different geographic areas. Sera collected 6 years earlier from both groups had limited neutralizing activity, indicating that early responses are not predictive for disease progression. LTNPs had very low virus loads, as reflected by only one positive isolation, which was an MT-2-negative phenotype. Virus was isolated from all FPs, and the isolates showed a phenotype switch from MT-2 negative to MT-2 positive. Development of high-titer, broadly cross-reactive neutralizing antibodies is associated with control of virus replication and low virus load in HIV-1-infected LTNPs.
比较了来自17名长期疾病无进展者（LTNP）和13名快速进展者（FP）的原发性人类免疫缺陷病毒1型（HIV-1）分离株的中和活性。LTNP的血清在效价和宿主谱方面均显示出比FP的血清更高的中和活性。然而，LTNP血清对来自不同地理区域的HIV-1亚型的中和活性有限。两组6年前收集的血清中和活性有限，这表明早期反应不能预测疾病进展。LTNP的病毒载量非常低，仅一次阳性分离就反映了这一点，该分离株为MT-2阴性表型。从所有FP中都分离出了病毒，并且分离株显示出从MT-2阴性到MT-2阳性的表型转换。高滴度、广泛交叉反应性中和抗体的产生与HIV-1感染的LTNP中病毒复制的控制和低病毒载量有关。
