源自放线菌的脯氨酰内肽酶抑制剂。

Prolyl endopeptidase inhibitors derived from actinomycetes.

作者信息

Kimura K, Kanou F, Yamashita Y, Yoshimoto T, Yoshihama M

机构信息

Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan.

出版信息

Biosci Biotechnol Biochem. 1997 Oct;61(10):1754-6. doi: 10.1271/bbb.61.1754.

DOI:10.1271/bbb.61.1754

PMID:9362123

Abstract

Four prolyl endopeptidase inhibitors isolated from actinomycetes, named propeptin, SNA-8073-B, staurosporine, and enduracidin were classified into 3 groups on the basis of their inhibition potency against prolyl endopeptidase from a bacterium (Flavobacterium) and a mammal (human placenta). Staurosporine inhibited the enzyme from Flavobacterium more strongly than that from human placenta. Enduracidin inhibited the enzyme from human placenta more strongly than that from Flavobacterium. Propeptin and SNA-8073-B, both new compounds, inhibited the enzymes from both origins to the same extent.

摘要

从放线菌中分离出的四种脯氨酰内肽酶抑制剂，即前肽素、SNA - 8073 - B、星形孢菌素和耐久霉素，根据它们对来自一种细菌（黄杆菌）和一种哺乳动物（人胎盘）的脯氨酰内肽酶的抑制效力被分为3组。星形孢菌素对黄杆菌中的该酶的抑制作用比对人胎盘中的更强。耐久霉素对人胎盘中的该酶的抑制作用比对黄杆菌中的更强。前肽素和SNA - 8073 - B这两种新化合物对来自这两种来源的酶的抑制程度相同。