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血管手术对截肢率和死亡率的影响。

Effects of vascular surgery on amputation rates and mortality.

作者信息

Karlström L, Bergqvist D

机构信息

Kirurgkliniken, Norra Alvsborgs Länssjukhus, Trollhättan, Sweden.

出版信息

Eur J Vasc Endovasc Surg. 1997 Oct;14(4):273-83. doi: 10.1016/s1078-5884(97)80239-0.

DOI:10.1016/s1078-5884(97)80239-0
PMID:9366791
Abstract

OBJECTIVES

To study the relation between rates of vascular interventions, amputations and mortality in a defined population.

DESIGN

Retrospective comparison between two consecutive 4-year periods.

SETTING

Swedish district hospital covering a population of 125,000.

MATERIAL

Three hundred and sixty-seven lower limb amputations and 1080 vascular procedures.

RESULTS

The number of legs treated for limb-threatening ischaemia with either revascularisation or amputation increased from 269 to 289. The rate of vascular interventions for limb-threatening ischaemia increased from the first to the second period by 65%, while the rate of amputations decreased by 23%. Limb salvage rate at 30 months increased from 37% to 53% (p < 0.0000). The reduced amputation rate was entirely related to primary amputations. The adjusted risk of amputation for patients treated in the second period was half of that for patients treated in the first period (relative risk = 0.49, p = 0.0001), while mortality was similar in both periods. Among survivors, the proportion of patients with intact legs was higher in the second period than in the first, while no difference was found between the two periods among deceased patients.

CONCLUSIONS

Increased vascular intervention leads to improved limb salvage rates and reduced amputation rates. It is important for both ethical and economical reasons to identify good responders to revascularisation, because the choice of initial treatment will only influence limb salvage but not survival.

摘要

目的

研究特定人群中血管介入治疗率、截肢率与死亡率之间的关系。

设计

对两个连续的4年时间段进行回顾性比较。

地点

覆盖12.5万人口的瑞典地区医院。

资料

367例下肢截肢手术和1080例血管手术。

结果

因肢体威胁性缺血接受血运重建或截肢治疗的下肢数量从269例增加至289例。因肢体威胁性缺血进行血管介入治疗的比率从第一个时间段到第二个时间段增加了65%,而截肢率下降了23%。30个月时的保肢率从37%提高到53%(p<0.0000)。截肢率的降低完全与一期截肢有关。第二个时间段接受治疗的患者截肢的校正风险是第一个时间段接受治疗患者的一半(相对风险=0.49,p=0.0001),而两个时间段的死亡率相似。在幸存者中,第二个时间段腿部完好的患者比例高于第一个时间段,而在死亡患者中两个时间段未发现差异。

结论

增加血管介入治疗可提高保肢率并降低截肢率。出于伦理和经济原因,识别血运重建的良好反应者很重要,因为初始治疗的选择仅会影响保肢情况而不会影响生存。

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