Hayakawa A, Kuwata K, Era S, Sogami M, Shimonaka H, Yamamoto M, Dohi S, Hirose H
Department of Anesthesiology, Gifu University School of Medicine, Japan.
J Chromatogr B Biomed Sci Appl. 1997 Sep 26;698(1-2):27-33. doi: 10.1016/s0378-4347(97)00274-0.
Human serum albumin is a mixture of mercapt- (HMA, reduced form) and nonmercaptalbumin (HNA, oxidized form). We studied the mercapt<-->nonmercapt conversion of human serum albumin, which reflects the redox state of the extracellular fluids, in cardiac and other common surgical_ patients using high-performance liquid chromatography. Mean values of [(HMA)/(HMA+HNA)]+/-standard deviation, fHMA+/-sigma], for patients who received common surgery (group 1) and cardiac surgery (group 2) at the start of anesthesia were 0.636+/-0.050 (n = 83) and 0.615+/-0.062 (n = 14), respectively. fHMA values were markedly lower than those for healthy male adults of 0.750+/-0.028 (n = 28). fHMA values increased at 24 h after the start of anesthesia and decreased on the 4th postoperative day in most of the patients. These postoperative changes were prominent in cardiac surgical patients. Although fHMA values after the 7th postoperative day recovered to those at the start of anesthesia in almost all of common surgical patients, those in cardiac surgical patients never recovered even on the 21st postoperative day.
人血清白蛋白是巯基白蛋白（HMA，还原形式）和非巯基白蛋白（HNA，氧化形式）的混合物。我们使用高效液相色谱法研究了心脏及其他普通外科手术患者中人血清白蛋白的巯基<-->非巯基转化情况，该转化反映了细胞外液的氧化还原状态。在麻醉开始时，接受普通手术的患者（第1组）和心脏手术的患者（第2组）的[(HMA)/(HMA+HNA)]±标准差，即fHMA±σ的平均值分别为0.636±0.050（n = 83）和0.615±0.062（n = 14）。fHMA值明显低于健康成年男性的0.750±0.028（n = 28）。多数患者在麻醉开始后24小时fHMA值升高，术后第4天降低。这些术后变化在心脏手术患者中尤为明显。尽管几乎所有普通外科手术患者术后第7天的fHMA值恢复到麻醉开始时的水平，但心脏手术患者即使在术后第21天也未恢复。
