Klausen T, Olsen N V, Poulsen T D, Richalet J P, Pedersen B K
Department of Rheumatology and Immunology, Hvidore Hospital, University of Copenhagen, Denmark.
Eur J Appl Physiol Occup Physiol. 1997;76(5):480-2. doi: 10.1007/s004210050278.
Serum concentrations of interleukin (IL) 1 beta, IL-1 receptor antagonist (IL-1ra), IL-6, tumor necrosis factor (TNF) alpha, and C-reactive protein (CRP) were determined in ten healthy men at sea level and during four days of altitude hypoxia (4350m above sea level). The mean (SD) arterial blood oxygen saturations were 78.6 (7.3)%, 82.4 (4.9)%, and 83.4 (5.3)% in the first, second, and third days at altitude, respectively. A symptom score of acute mountain sickness (AMS) revealed that the subjects had mostly light symptoms of AMS. Mean serum IL-6 increased from 1.36 (1.04) pg x ml(-1) at sea level to 3.10 (1.65), 4.71 (2.81), and 3,54 (2.17) pg x ml(-1) during the first three days at altitude, and to 9.96 (8.90) pg x ml(-1) on the fourth day at altitude (ANOVA p = 0.002). No changes occurred in serum concentrations of IL-1 beta, IL-1ra, TNF alpha, or CRP. The serum IL-6 were related to SaO2, (r = -0.45, p = 0.003), but not to heart rates or AMS scores. In conclusion, human serum concentrations of IL-6 increased during altitude hypoxia whereas the other proinflammatory cytokines remained unchanged. The major role of IL-6 during altitude hypoxia seem not to be mediation of inflammation, instead, the role of IL-6 could be to stimulate the erythropoiesis at altitude.
在海平面及海拔4350米的高原进行为期四天的低氧环境期间，对10名健康男性的血清白细胞介素（IL）-1β、IL-1受体拮抗剂（IL-1ra）、IL-6、肿瘤坏死因子（TNF）-α和C反应蛋白（CRP）浓度进行了测定。在高原的第一天、第二天和第三天，平均（标准差）动脉血氧饱和度分别为78.6（7.3）%、82.4（4.9）%和83.4（5.3）%。急性高山病（AMS）症状评分显示，受试者大多有轻度AMS症状。平均血清IL-6浓度从海平面时的1.36（1.04）pg/ml升高至高原前三天的3.10（1.65）、4.71（2.81）和3.54（2.17）pg/ml，并在高原第四天升至9.96（8.90）pg/ml（方差分析p = 0.002）。血清IL-1β、IL-1ra、TNF-α或CRP浓度无变化。血清IL-6与血氧饱和度（SaO2）相关（r = -0.45，p = 0.003），但与心率或AMS评分无关。总之，高原低氧环境期间人体血清IL-6浓度升高，而其他促炎细胞因子保持不变。IL-6在高原低氧环境中的主要作用似乎不是介导炎症，相反，IL-6的作用可能是刺激高原地区的红细胞生成。
