Koyama A H, Adachi A
Department of Virology, School of Medicine, The University of Tokushima, Japan.
J Gen Virol. 1997 Nov;78 ( Pt 11):2909-12. doi: 10.1099/0022-1317-78-11-2909.
Although herpes simplex virus type 1 (HSV-1) does not induce apoptosis in infected HEp-2 cells, in the presence of cycloheximide infection induced apoptosis with characteristic morphological changes as well as endonucleosomal DNA cleavage. The induction of apoptosis without de novo protein synthesis suggests that a structural protein of the HSV-1 virion is responsible for the observed apoptosis.
虽然1型单纯疱疹病毒（HSV-1）在感染的HEp-2细胞中不会诱导细胞凋亡，但在放线菌酮存在的情况下，感染会诱导细胞凋亡，并伴有特征性的形态变化以及核小体间DNA裂解。在没有从头合成蛋白质的情况下诱导细胞凋亡，这表明HSV-1病毒体的一种结构蛋白是观察到的细胞凋亡的原因。
