Polosukhin V V
Laboratory of Laser Researches of Lymphatic System, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, Russia.
Virchows Arch. 1997 Oct;431(4):283-90. doi: 10.1007/s004280050100.
An ultrastructural and autoradiographic analysis of changes in 188 biopsy specimens of bronchial mucosa of the large bronchi from 76 patients with chronic inflammatory lung diseases was carried out. Fibrosis results in an apparent reduction of metabolic activity in endothelial cells, affecting the proliferation of basal cells with changes in cell differentiation. Endobronchial laser therapy with an helium-neon laser induces proliferative and metabolic processes in the lamina propria of the bronchial mucosa with hyperaemia, intensive diapedesis of leucocytes and formation of leucocytic infiltrations and granulation tissue. The proliferative and metabolic activity of endothelial and stromal cells increases, and delicate fibrous connective tissue is formed.
对76例慢性炎症性肺疾病患者的188份大支气管支气管黏膜活检标本进行了超微结构和放射自显影分析。纤维化导致内皮细胞代谢活性明显降低，影响基底细胞增殖并伴有细胞分化改变。氦氖激光支气管内激光治疗可诱导支气管黏膜固有层出现增殖和代谢过程，伴有充血、白细胞大量渗出以及白细胞浸润和肉芽组织形成。内皮细胞和基质细胞的增殖和代谢活性增加，并形成纤细的纤维结缔组织。
