Polosukhin V V
Laboratory of Laser Researches of Lymphatic System, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Pathol Res Pract. 1996 Sep;192(9):909-18. doi: 10.1016/S0344-0338(96)80072-0.
Investigation of structural and metabolic changes in 188 biopsy specimens from the epithelium of large bronchi of 76 patients with chronic lung disease was carried out. It was shown that endobronchial treatment by helium-neon laser irradiation induced the proliferative and metabolic processes in damaged epithelium, which after getting through the series of transitional forms restores its normal structure and differentiation into ciliated and goblet cells of a normal ultrastructure. The hyperemia, intensive diapedesis of leucocytes, the formation of leucocytic infiltrations and granulations develop in the lamina propria of the bronchial mucosa. Proliferative and metabolic activity of the endotheliocytes and stromal cells increases. Finally, delicate-fibrous connective tissue forms. The simultaneous reorganizations of the epithelium and underlying connective tissue is interpreted from the point of view of the concept of parenchymal-stromal interactions.
对76例慢性肺病患者大支气管上皮的188份活检标本进行了结构和代谢变化的研究。结果表明，氦氖激光照射支气管内治疗可诱导受损上皮的增殖和代谢过程，该上皮经过一系列过渡形式后恢复其正常结构，并分化为具有正常超微结构的纤毛细胞和杯状细胞。支气管黏膜固有层出现充血、白细胞强烈渗出、白细胞浸润和肉芽形成。内皮细胞和基质细胞的增殖和代谢活性增加。最后形成纤细的纤维结缔组织。从实质-基质相互作用的概念角度解释了上皮和其下方结缔组织的同时重组。
