Hjartåker A, Lund E, Bjerve K S
Institute of Community Medicine, University of Tromsø, Norway.
Eur J Clin Nutr. 1997 Nov;51(11):736-42. doi: 10.1038/sj.ejcn.1600475.
To examine the relation between consumption of fish and fish products registered by a comprehensive food frequency questionnaire and the composition of fatty acids in serum phospholipids.
Cross-section study.
Cardiovascular screening centre in Trondheim, Mid-Norway.
Of 256 eligible women 242 agreed to participate in the present study. Altogether 234 middle-aged women (91.4%) completed the questionnaire and gave a valid blood sample.
Total frequency consumption of fish for dinner showed only weak association with serum phospholipid fatty acid composition. In separate analyses of lean and fatty fish, consumption of fatty fish was negatively associated with n-6 and positively associated with n-3 fatty acids in serum phospholipids, while no significant associations were found for lean fish consumption. Cod liver oil consumption was strongly related to the phospholipid fatty acid composition. The associations improved moderately when adding portion size information. Spearman's correlation coefficient between dietary intake of eicosapentaenoic acid (EPA) and serum phospholipid EPA was 0.58, and Spearman's correlation coefficient between intake of docosahexaenoic acid (DHA) and serum phospholipid DHA was 0.53.
This study suggests that in populations with a high consumption of fish and cod liver oil, habitual intake can be reflected in serum phospholipids. However, as the fat content of fish is highly variable, separate registration of lean and fatty fish consumption is needed.
通过综合食物频率问卷研究鱼类及鱼类产品的摄入量与血清磷脂中脂肪酸组成之间的关系。
横断面研究。
挪威中部特隆赫姆的心血管筛查中心。
256名符合条件的女性中，242名同意参与本研究。共有234名中年女性（91.4%）完成了问卷调查并提供了有效的血样。
晚餐食用鱼类的总频率与血清磷脂脂肪酸组成仅呈微弱关联。在对瘦肉型鱼和多脂鱼的单独分析中，食用多脂鱼与血清磷脂中的n-6脂肪酸呈负相关，与n-3脂肪酸呈正相关，而食用瘦肉型鱼未发现显著关联。食用鱼肝油与磷脂脂肪酸组成密切相关。添加份量信息后，这种关联适度改善。二十碳五烯酸（EPA）的膳食摄入量与血清磷脂EPA之间的Spearman相关系数为0.58，二十二碳六烯酸（DHA）的摄入量与血清磷脂DHA之间的Spearman相关系数为0.53。
本研究表明，在鱼类和鱼肝油消费量较高的人群中，习惯性摄入量可反映在血清磷脂中。然而，由于鱼类的脂肪含量差异很大，需要分别记录瘦肉型鱼和多脂鱼的消费量。
