Andersen V, Cohn J, Sorensen S F
Acta Paediatr Scand. 1976 Jul;65(4):409-15. doi: 10.1111/j.1651-2227.1976.tb04907.x.
Fourteen children underwent splenectomy for congenital spherocytosis, splenomegaly, or thrombocytopenia. The patients were studied twice before the operation, three times during the first postoperative month, and one year later. A transitory rise in neutrophils and serum IgA was seen postoperatively; there was a modest but long-lasting increase in lymphocytes and a marked elevation of eosinophils. An immediate decline in serum IgM concentration was observed only in patients with an uncomplicated postoperative course, but one year after splenectomy the average IgM concentration had decreased by 23%. The in vitro lymphocyte transformation response to a panel of mitogens and antigens fell in the immediate postoperative period but was largely normalized 10 days postoperatively, except in the youngest of the patients who had repeated infections following the splenectomy. One year postoperatively the transformation response and the number of T- and B-lymphocytes in the blood were normal.
14名儿童因先天性球形红细胞增多症、脾肿大或血小板减少症接受了脾切除术。在手术前对患者进行了两次研究，术后第一个月进行了三次研究，一年后又进行了一次研究。术后可见中性粒细胞和血清IgA短暂升高；淋巴细胞有适度但持久的增加，嗜酸性粒细胞显著升高。仅在术后过程无并发症的患者中观察到血清IgM浓度立即下降，但脾切除术后一年，平均IgM浓度下降了23%。术后即刻，淋巴细胞对一组有丝分裂原和抗原的体外转化反应下降，但术后10天基本恢复正常，除了最年幼的患者，他们在脾切除术后反复感染。术后一年，血液中的转化反应以及T淋巴细胞和B淋巴细胞数量均正常。
