Calvo J L, Boya J, Carbonell A L, García-Mauriño J E
Department of Histology, Faculty of Medicine, Complutense University, Madrid, Spain.
J Pineal Res. 1997 Aug;23(1):1-4. doi: 10.1111/j.1600-079x.1997.tb00327.x.
The cellular proliferative activity in the adult rat pineal gland was studied using bromodeoxyuridine immunohistochemistry during the light and dark phases of an artificial 12L:12D photoperiod. The results showed statistically significant differences in the number of labeled cells between the light and dark phases, with the labeled cells being almost threefold more abundant in the light period. Minor changes were also found in the pineal gland volume between both periods. The decrease in the number of labeled cells in the dark phase of the cycle could be related to the well-documented antimitotic action of melatonin.
在人工12小时光照：12小时黑暗光周期的光照和黑暗阶段，使用溴脱氧尿苷免疫组织化学法研究成年大鼠松果体中的细胞增殖活性。结果显示，光照和黑暗阶段标记细胞数量存在统计学上的显著差异，光照期标记细胞数量几乎多出两倍。两个阶段的松果体体积也有微小变化。周期黑暗阶段标记细胞数量的减少可能与褪黑素已被充分证明的抗有丝分裂作用有关。
