庆大霉素和阿米卡星在人肾脏中的浓度。
Concentrations of gentamicin and amikacin in human kidneys.
作者信息
Edwards C Q, Smith C R, Baughman K L, Rogers J F, Lietman P S
出版信息
Antimicrob Agents Chemother. 1976 Jun;9(6):925-7. doi: 10.1128/AAC.9.6.925.
High kidney concentrations of gentamicin or amikacin, measured by an enzymological assay, were found in 9 of 10 patients who died during therapy with these aminoglycosides. Renal cortical concentrations of gentamicin ranged from 140 to 540 mug/g of tissue, with medullary levels of 128 to 230 mug/g. Concentrations of amikacin ranged from 365 to 1,030 mug/g in the cortex and from 270 to 718 mug/g in the medulla. The only patient with low kidney concentrations was an infant who received a single dose of gentamicin. Tissue levels were high in patients with both normal and abnormal renal function. Our results indicate that gentamicin and amikacin are concentrated in renal cortical and medullary tissue.
通过酶学测定法测得，在接受这些氨基糖苷类药物治疗期间死亡的10名患者中，有9名患者的肾脏中庆大霉素或阿米卡星浓度较高。庆大霉素在肾皮质中的浓度范围为每克组织140至540微克，髓质中的水平为每克128至230微克。阿米卡星在皮质中的浓度范围为每克365至1030微克，在髓质中的浓度范围为每克270至718微克。唯一肾脏浓度较低的患者是一名接受单剂量庆大霉素的婴儿。肾功能正常和异常的患者组织水平都很高。我们的结果表明，庆大霉素和阿米卡星在肾皮质和髓质组织中浓缩。
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