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The effect of digoxin on mortality and morbidity in patients with heart failure.地高辛对心力衰竭患者死亡率和发病率的影响。
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Evaluation by patients with heart failure of the effects of enalapril compared with hydralazine plus isosorbide dinitrate on quality of life. V-HeFT II. The V-HeFT VA Cooperative Studies Group.心力衰竭患者对依那普利与肼屈嗪加硝酸异山梨酯对生活质量影响的评估。V-HeFT II。V-HeFT VA协作研究组。
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Prognostic significance of serial changes in left ventricular ejection fraction in patients with congestive heart failure. The V-HeFT VA Cooperative Studies Group.充血性心力衰竭患者左心室射血分数的系列变化的预后意义。V-HeFT VA合作研究组。
Circulation. 1993 Jun;87(6 Suppl):VI17-23.
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A multicentre, double-blind, placebo-controlled trial of quinapril in mild, chronic heart failure.一项关于喹那普利治疗轻度慢性心力衰竭的多中心、双盲、安慰剂对照试验。
Eur Heart J. 1993 Mar;14(3):403-9. doi: 10.1093/eurheartj/14.3.403.
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Bedside cardiovascular examination in patients with severe chronic heart failure: importance of rest or inducible jugular venous distension.重度慢性心力衰竭患者的床边心血管检查:静息或诱发性颈静脉扩张的重要性
J Am Coll Cardiol. 1993 Oct;22(4):968-74. doi: 10.1016/0735-1097(93)90405-p.
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Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED trial. PROVED Investigative Group.评估地高辛撤药对轻至中度慢性充血性心力衰竭患者影响的随机研究:PROVED试验结果。PROVED研究组
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Heart failure in the 1990s: evolution of a major public health problem in cardiovascular medicine.20世纪90年代的心力衰竭:心血管医学领域一个重大公共卫生问题的演变
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Perspective of the pharmaceutical industry on the development of new drugs for heart failure.
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Quality of life among 5,025 patients with left ventricular dysfunction randomized between placebo and enalapril: the Studies of Left Ventricular Dysfunction. The SOLVD Investigators.5025例左心室功能不全患者在安慰剂和依那普利之间随机分组后的生活质量:左心室功能不全研究。SOLVD研究人员。
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在心肌病门诊就诊的患者症状改善且住院次数减少。

Symptomatic improvement and reduced hospitalization for patients attending a cardiomyopathy clinic.

作者信息

Smith L E, Fabbri S A, Pai R, Ferry D, Heywood J T

机构信息

Cardiology Section, Jerry L. Pettis Veterans Administration Medical Center, Loma Linda, California 92354, USA.

出版信息

Clin Cardiol. 1997 Nov;20(11):949-54. doi: 10.1002/clc.4960201109.

DOI:10.1002/clc.4960201109
PMID:9383589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6655719/
Abstract

BACKGROUND

The major costs associated with the management of congestive heart failure (CHF) are inpatient costs. Outcome studies are therefore important to establish whether intensive outpatient care for heart failure can reduce these costs while at the same time improving outcomes in this disabling disorder.

HYPOTHESIS

Care delivered in a cardiomyopathy clinic might result in objective improvement in cardiac function and symptoms while reducing hospital admissions and emergency department visits.

METHODS

The outcomes of 21 patients treated for 6 months in a cardiomyopathy clinic are evaluated. New patients referred to the clinic with ejection fraction (EF) < 0.45 were enrolled. The Minnesota Living with Heart Failure questionnaire was completed at initial and final visits. All patients underwent baseline and final echocardiogram, radionuclide left ventriculogram, and cardiopulmonary exercise testing. Patients were followed by a nurse practitioner and a cardiologist with maximization of standard treatment. Congestive heart failure-related hospitalizations and clinic and emergency room visits for both 6-month periods before and during the study were determined.

RESULTS

There was significant (p < 0.05) improvement in these parameters: Heart failure score increased 23 points; New York Heart Association class decreased from 2.6 to 2.2; EF increased from 0.24 to 0.36; diastolic and systolic left ventricular dimensions decreased from 65 to 59 mm and from 57 to 50 mm, respectively. The number of clinic visits increased 5-fold, whereas there were 86% (14 to 2, p = 0.017) and 100% (8 to 0, p = 0.002) reductions in the number of CHF hospitalizations and emergency visits. There was one death during follow-up.

CONCLUSION

Managing patients in a cardiomyopathy clinic may result in a better quality of life, with both symptomatic improvement and decreased hospitalizations.

摘要

背景

与充血性心力衰竭(CHF)管理相关的主要费用是住院费用。因此,结果研究对于确定心力衰竭的强化门诊护理能否在降低这些费用的同时改善这种致残性疾病的预后非常重要。

假设

在心肌病诊所提供的护理可能会在改善心脏功能和症状的同时减少住院次数和急诊就诊次数。

方法

评估了21名在心肌病诊所接受6个月治疗的患者的结果。纳入了因射血分数(EF)<0.45转诊至该诊所的新患者。在初次和末次就诊时完成明尼苏达心力衰竭生活问卷。所有患者均接受了基线和末次超声心动图、放射性核素左心室造影和心肺运动测试。由一名执业护士和一名心脏病专家对患者进行随访,并将标准治疗最大化。确定了研究前和研究期间6个月内与充血性心力衰竭相关的住院次数以及诊所和急诊室就诊次数。

结果

这些参数有显著(p<0.05)改善:心力衰竭评分增加23分;纽约心脏协会分级从2.6降至2.2;EF从0.24增至0.36;舒张期和收缩期左心室直径分别从65毫米降至59毫米和从57毫米降至50毫米。诊所就诊次数增加了5倍,而充血性心力衰竭住院次数和急诊就诊次数分别减少了86%(从14次降至2次,p=0.017)和100%(从8次降至0次,p=0.002)。随访期间有1例死亡。

结论

在心肌病诊所管理患者可能会改善生活质量,症状得到改善且住院次数减少。