Cullen D J, Hawkey G M, Greenwood D C, Humphreys H, Shepherd V, Logan R F, Hawkey C J
Division of Gastroenterology, University Hospital, Nottingham, UK.
Gut. 1997 Oct;41(4):459-62. doi: 10.1136/gut.41.4.459.
Most ulcers are caused, one can deduce, by Helicobacter pylori or by use of non-steroidal anti-inflammatory drugs (NSAIDs). Whether both together are worse than one alone is something that is quite unknown.
To study both factors in order to see wither they interact together positively.
A case control study of ulcer bleeding in elderly patients chosen without weeding.
NSAID usage increased risk substantially. So did H pylori infection (but relative risk less than three). Neither seemed to interact. Their actions were discretely intact.
H pylori effects ulcer bleeding in an adverse manner but does not make the risk of NSAIDs worse.
可以推断,大多数溃疡是由幽门螺杆菌或使用非甾体抗炎药(NSAIDs)引起的。两者共同作用是否比单独一种因素更严重尚不清楚。
研究这两种因素,以观察它们是否产生正向相互作用。
对老年溃疡出血患者进行病例对照研究,未进行筛选。
使用NSAIDs会大幅增加风险。幽门螺杆菌感染也是如此(但相对风险小于3)。两者似乎没有相互作用。它们的作用各自独立。
幽门螺杆菌以不良方式影响溃疡出血,但不会使NSAIDs的风险增加。