Kaş H S
Hacettepe University, Pharmacy Faculty, Pharmaceutical Technology Department, Ankara, Turkey.
J Microencapsul. 1997 Nov-Dec;14(6):689-711. doi: 10.3109/02652049709006820.
Chitosan, a hydrophilic biopolymer, is obtained industrially by hydrolysing the aminoacetyl groups of chitin. It is a natural, non-toxic, biodegradable polysaccharide available as solution, flake, fine powder, bead and fibre. The sources, biochemical aspects, structure and chemical modification, physico-chemical and functional properties, and applications of chitosan have been investigated extensively in the literature. In this paper, the attractive properties and broad applications of chitosan-based microparticles, their versatile properties, different preparation methods, and pharmaceutical and biopharmaceutical applications are reviewed.
壳聚糖是一种亲水性生物聚合物，通过水解几丁质的氨基乙酰基在工业上获得。它是一种天然、无毒、可生物降解的多糖，有溶液、片状、细粉、珠子和纤维等形式。壳聚糖的来源、生化方面、结构和化学修饰、物理化学和功能特性以及应用在文献中已得到广泛研究。本文综述了壳聚糖基微粒的诱人特性和广泛应用、它们的多种特性、不同的制备方法以及药物和生物制药应用。
