Sinha V R, Singla A K, Wadhawan S, Kaushik R, Kumria R, Bansal K, Dhawan S
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Int J Pharm. 2004 Apr 15;274(1-2):1-33. doi: 10.1016/j.ijpharm.2003.12.026.
Chitosan is a biodegradable natural polymer with great potential for pharmaceutical applications due to its biocompatibility, high charge density, non-toxicity and mucoadhesion. It has been shown that it not only improves the dissolution of poorly soluble drugs but also exerts a significant effect on fat metabolism in the body. Gel formation can be obtained by interactions of chitosans with low molecular counterions such as polyphosphates, sulphates and crosslinking with glutaraldehyde. This gelling property of chitosan allows a wide range of applications such as coating of pharmaceuticals and food products, gel entrapment of biochemicals, plant embryo, whole cells, microorganism and algae. This review is an insight into the exploitation of the various properties of chitosan to microencapsulate drugs. Various techniques used for preparing chitosan microspheres and evaluation of these microspheres have also been reviewed. This review also includes the factors that affect the entrapment efficiency and release kinetics of drugs from chitosan microspheres.
壳聚糖是一种可生物降解的天然聚合物，因其生物相容性、高电荷密度、无毒性和粘膜粘附性而在药物应用方面具有巨大潜力。研究表明，它不仅能改善难溶性药物的溶解，还对体内脂肪代谢有显著影响。壳聚糖与低分子抗衡离子如多磷酸盐、硫酸盐相互作用以及与戊二醛交联可形成凝胶。壳聚糖的这种凝胶特性使其具有广泛的应用，如药物和食品的包衣、生化物质、植物胚胎、全细胞、微生物和藻类的凝胶包封。本综述深入探讨了利用壳聚糖的各种特性对药物进行微囊化。还综述了用于制备壳聚糖微球的各种技术以及对这些微球的评价。本综述还包括影响药物从壳聚糖微球中的包封效率和释放动力学的因素。
